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Metabolomic analysis of coelomic fluids reveals the physiological mechanisms underlying evisceration behavior in the sea cucumber Apostichopus japonicus 期刊论文
AQUACULTURE, 2021, 卷号: 543, 页码: 9
作者:  Ding, Kui;  Zhang, Libin;  Huo, Da;  Guo, Xueying;  Liu, Xiang;  Zhang, Shuangli
Adobe PDF(1516Kb)  |  收藏  |  浏览/下载：201/0  |  提交时间：2021/12/07
Echinoderm  Sea cucumber  Evisceration  Metabolite  Metabolic pathway  
Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 卷号: 297, 期号: 4, 页码: 12
作者:  Liu, Ge;  Liu, Rui;  Shan, Yeqi;  Sun, Chaomin
Adobe PDF(3926Kb)  |  收藏  |  浏览/下载：200/0  |  提交时间：2022/01/05
Novel poly (ADP-ribose) polymerases inhibitor DHC-1 exhibits in vitro and in vivo anticancer activity on BRCA-deficient pancreatic cancer cells 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2021, 卷号: 147, 页码: 10
作者:  Wu, Xiaochen;  Li, Qiqi;  Zhang, Fan;  Wang, Lijun;  Wang, Jun;  Fan, Junting;  Di, Guohu;  Guo, Chuanlong
Adobe PDF(8144Kb)  |  收藏  |  浏览/下载：198/0  |  提交时间：2021/04/21
PARP inhibitor  BRCA  Pancreatic cancer  
Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications 期刊论文
CARBOHYDRATE POLYMERS, 2020, 卷号: 236, 页码: 17
作者:  Qin, Yukun;  Li, Pengcheng;  Guo, Zhanyong
Adobe PDF(1903Kb)  |  收藏  |  浏览/下载：165/0  |  提交时间：2020/09/22
Cationic chitosan derivatives  Antifungals  Structural optimization strategy  Antifungal therapy  
BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 150, 页码: 238-245
作者:  Guo, Chuanlong;  Zhang, Fan;  Wu, Xiaochen;  Yu, Xuemin;  Wu, Xianggen;  Shi, Dayong;  Wang, Lijun
Adobe PDF(1767Kb)  |  收藏  |  浏览/下载：229/0  |  提交时间：2020/09/23
PARP-1 inhibitor  DNA double-strand breaks  HCC-1937  In vivo  Apoptosis  
The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21, 期号: 3, 页码: 15
作者:  Zhang, Jiajia;  Dai, Jiajia;  Zheng, Qingxuan;  Guo, Shuju;  Yu, Yanyan;  Hu, Wenpeng;  Gao, Yanan;  Shi, Dayong
Adobe PDF(2858Kb)  |  收藏  |  浏览/下载：189/0  |  提交时间：2020/09/23
triple negative breast cancer  MDA-MB-231 cells  fluoro-thiazolylhydrazone  MAPK pathway  phosphorylated p44/42 MAPK (ERK1/2)  phosphorylated c-Jun N-terminal kinase (p-JNK)  apoptosis  
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway 期刊论文
FASEB JOURNAL, 2019, 卷号: 33, 期号: 9, 页码: 10089-10103
作者:  Liu, Ge;  Kuang, Shan;  Cao, Ruobing;  Wang, Ju;  Peng, Quancai;  Sun, Chaomin
Adobe PDF(2281Kb)  |  收藏  |  浏览/下载：345/0  |  提交时间：2019/11/14
stearoyl CoA desaturase 1  monounsaturated FAs  ATP production  
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  收藏  |  浏览/下载：371/0  |  提交时间：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
The Multifaceted Roles of Pyroptotic Cell Death Pathways in Cancer 期刊论文
CANCERS, 2019, 卷号: 11, 期号: 9, 页码: 26
作者:  Wang, Man;  Jiang, Shuai;  Zhang, Yinfeng;  Li, Peifeng;  Wang, Kun
Adobe PDF(2571Kb)  |  收藏  |  浏览/下载：280/0  |  提交时间：2020/01/03
pyroptosis  cancer  inflammasome  gasdermin  pro-inflammatory cytokine  cancer pathogenesis  therapeutic utility  
Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7 '-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 6, 页码: 3640-3652
作者:  Liu, Yang;  Mandi, Attila;  Li, Xiao-Ming;  Meng, Ling-Hong;  Kurtan, Tibor;  Wang, Bin-Gui
Adobe PDF(1389Kb)  |  收藏  |  浏览/下载：451/0  |  提交时间：2015/12/07
Marine Sponge  Endophytic Fungus  Penicillium Adametzioides  Secondary Metabolites  Antifungal Activity