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Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 160, 页码: 496-505
Authors:  Wang, Jun;  Wang, Lijun;  Zhang, Shuhong;  Fan, Junting;  Yang, Hui;  Li, Qiqi;  Guo, Chuanlong
Favorite  |  View/Download：11/0  |  Submit date：2020/10/26
eIF4E/eIF4G  Human lung cancer  Apoptosis  DNA damage  ROS  
卤代噻唑胺基类化合物的抗三阴性乳腺癌活性研究 学位论文
工学硕士学位, 中国科学院海洋研究所: 中国科学院大学, 2020
Authors:  张佳佳
Adobe PDF(1995Kb)  |  Favorite  |  View/Download：22/0  |  Submit date：2020/06/11
卤代噻唑  抗肿瘤  三阴性乳腺癌  Mda-mb-231  
The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2020, 卷号: 137, 页码: 10
Authors:  Guo, Chuanlong;  Hou, Yuzhen;  Yu, Xuemin;  Zhang, Fan;  Wu, Xiaochen;  Wu, Xianggen;  Wang, Lijun
Favorite  |  View/Download：2/0  |  Submit date：2020/09/22
Apoptosis  eIF4F  ERK  MNK  A549 cells  
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
Authors:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  Favorite  |  View/Download：45/0  |  Submit date：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
海洋溴酚化合物抗肿瘤活性筛选及作用机制研究 学位论文
理学博士, 中国科学院海洋研究所: 中国科学院大学, 2019
Authors:  郭传龙
Adobe PDF(9521Kb)  |  Favorite  |  View/Download：73/0  |  Submit date：2019/06/17
海洋溴酚化合物  抗肿瘤  Eif4e  Parp-1抑制剂