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中国科学院海洋研究所机构知识库
Knowledge Management System Of Institute of Oceanology, Chinese Academy of Sciences
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海洋生物技术研发中心 [1]
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Yang Hui [1]
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Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 160, 页码: 496-505
Authors:
Wang, Jun
;
Wang, Lijun
;
Zhang, Shuhong
;
Fan, Junting
;
Yang, Hui
;
Li, Qiqi
;
Guo, Chuanlong
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View/Download:11/0
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Submit date:2020/10/26
eIF4E/eIF4G
Human lung cancer
Apoptosis
DNA damage
ROS
BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 150, 页码: 238-245
Authors:
Guo, Chuanlong
;
Zhang, Fan
;
Wu, Xiaochen
;
Yu, Xuemin
;
Wu, Xianggen
;
Shi, Dayong
;
Wang, Lijun
Adobe PDF(1767Kb)
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View/Download:3/0
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Submit date:2020/09/23
PARP-1 inhibitor
DNA double-strand breaks
HCC-1937
In vivo
Apoptosis
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study
期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
Authors:
Li, Xiuxue
;
Wang, Lijun
;
Jia, Xiaoling
;
Guo, Chuanlong
;
Li, Chao
;
Zhang, Jiajia
;
Shi, Dayong
Adobe PDF(579Kb)
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View/Download:2/0
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Submit date:2020/09/23
Novel compound
Quantitation
UHPLC-TOF-MS
Pharmacokinetics
The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo
期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2020, 卷号: 137, 页码: 10
Authors:
Guo, Chuanlong
;
Hou, Yuzhen
;
Yu, Xuemin
;
Zhang, Fan
;
Wu, Xiaochen
;
Wu, Xianggen
;
Wang, Lijun
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View/Download:2/0
  |  
Submit date:2020/09/22
Apoptosis
eIF4F
ERK
MNK
A549 cells
Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway
期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 15
Authors:
Xu, Qi
;
Wu, Ning
;
Li, Xiangqian
;
Guo, Chuanlong
;
Li, Chao
;
Jiang, Bo
;
Wang, Huaizhi
;
Shi, Dayong
Adobe PDF(3632Kb)
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View/Download:32/0
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Submit date:2020/03/20
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
Authors:
Wang, Lijun
;
Guo, Chuanlong
;
Li, Xiuxue
;
Yu, Xuemin
;
Li, Xiangqian
;
Xu, Kuo
;
Jiang, Bo
;
Jia, Xiaoling
;
Li, Chao
;
Shi, Dayong
Adobe PDF(4835Kb)
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View/Download:45/0
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Submit date:2019/08/29
Bromophenol-thiazolylhydrazone hybrids
Synthesis
Multifunctional agents
eIF4E/eIF4G interaction
Autophagy
ROS
Chalcone-analogue fluorescent probes for detecting thiophenols in seawater samples
期刊论文
TALANTA, 2019, 卷号: 201, 页码: 301-308
Authors:
Liu, Hua
;
Guo, Chuanlong
;
Guo, Shuju
;
Fan, Junting
;
Wang, Lijun
;
Shi, Dayong
Adobe PDF(1820Kb)
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View/Download:41/0
  |  
Submit date:2019/08/29
Fluorescent probe
Thiophenol
Seawater sample
Chalcone
海洋溴酚化合物抗肿瘤活性筛选及作用机制研究
学位论文
理学博士, 中国科学院海洋研究所: 中国科学院大学, 2019
Authors:
郭传龙
Adobe PDF(9521Kb)
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View/Download:73/0
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Submit date:2019/06/17
海洋溴酚化合物
抗肿瘤
Eif4e
Parp-1抑制剂
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
Authors:
Guo, Chuanlong
;
Wang, Lijun
;
Zhao, Yue
;
Jiang, Bo
;
Luo, Jiao
;
Shi, Dayong
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View/Download:31/0
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Submit date:2019/08/28
bromophenol
apoptosis
autophagy
phosphoinositide 3-kinase
protein kinase B
mechanistic target of rapamycin signaling
reactive oxygen species
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2 ',3,3 '-Tetrabromo-4,4 ',5,5 '-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice
期刊论文
MOLECULAR PHARMACEUTICS, 2019, 卷号: 16, 期号: 5, 页码: 1839-1850
Authors:
Li, Chao
;
Luo, Jiao
;
Guo, Shuju
;
Jia, Xiaoling
;
Guo, Chuanlong
;
Li, Xiangqian
;
Xu, Qi
;
Shi, Dayong
Favorite
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View/Download:28/0
  |  
Submit date:2019/08/28
type 2 diabetes mellitus
protein tyrosine phosphatase 1B
insulin resistance
hypoglycemic activity
dyslipidemia