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Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 160, 页码: 496-505
作者:  Wang, Jun;  Wang, Lijun;  Zhang, Shuhong;  Fan, Junting;  Yang, Hui;  Li, Qiqi;  Guo, Chuanlong
Adobe PDF(3920Kb)  |  收藏  |  浏览/下载：195/0  |  提交时间：2020/10/26
eIF4E/eIF4G  Human lung cancer  Apoptosis  DNA damage  ROS  
BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 150, 页码: 238-245
作者:  Guo, Chuanlong;  Zhang, Fan;  Wu, Xiaochen;  Yu, Xuemin;  Wu, Xianggen;  Shi, Dayong;  Wang, Lijun
Adobe PDF(1767Kb)  |  收藏  |  浏览/下载：182/0  |  提交时间：2020/09/23
PARP-1 inhibitor  DNA double-strand breaks  HCC-1937  In vivo  Apoptosis  
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study 期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
作者:  Li, Xiuxue;  Wang, Lijun;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Chao;  Zhang, Jiajia;  Shi, Dayong
Adobe PDF(579Kb)  |  收藏  |  浏览/下载：154/0  |  提交时间：2020/09/23
Novel compound  Quantitation  UHPLC-TOF-MS  Pharmacokinetics  
The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2020, 卷号: 137, 页码: 10
作者:  Guo, Chuanlong;  Hou, Yuzhen;  Yu, Xuemin;  Zhang, Fan;  Wu, Xiaochen;  Wu, Xianggen;  Wang, Lijun
Adobe PDF(2640Kb)  |  收藏  |  浏览/下载：176/0  |  提交时间：2020/09/22
Apoptosis  eIF4F  ERK  MNK  A549 cells