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Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
Authors:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
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Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
Authors:  Guo, Chuanlong;  Wang, Lijun;  Zhao, Yue;  Jiang, Bo;  Luo, Jiao;  Shi, Dayong
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bromophenol  apoptosis  autophagy  phosphoinositide 3-kinase  protein kinase B  mechanistic target of rapamycin signaling  reactive oxygen species  
Discovery of Novel Bromophenol Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3051-3067
Authors:  Guo, Chuanlong;  Wang, Lijun;  Li, Xinxue;  Wang, Shuaiyu;  Yu, Xuemin;  Xu, Kuo;  Zhao, Yue;  Luo, Jiao;  Li, Xiangqian;  Jiang, Bo;  Shi, Dayong
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Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
Authors:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
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Anti-diabetic  PTP1B inhibitor  Selectivity  BKS db mice  Toxicity  
Mid-late Holocene rainfall variation in Taiwan: A high-resolution multi proxy record unravels the dual influence of the Asian monsoon and ENSO 期刊论文
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY, 2019, 卷号: 516, 页码: 139-151
Authors:  Chen, Jinxia;  Li, Tiegang;  Nan, Qingyun;  Shi, Xuefa;  Liu, Yanguang;  Jiang, Bo;  Zou, Jianjun;  Selvaraj, Kandasamy;  Li, Dongling;  Li, Chuanshun
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Fern spore  C/N ratio  La Nina  Tropical cyclone  Okinawa Trough  
CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 15
Authors:  Luo, Jiao;  Jiang, Bo;  Li, Chao;  Jia, Xiaoling;  Shi, Dayong
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brominated organic compounds  hypoglycemic activity  insulin-sensitizing effect  RBPs  RNA splicing  
Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1 alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells 期刊论文
ANTI-CANCER DRUGS, 2018, 卷号: 29, 期号: 10, 页码: 965-974
Authors:  Guo, Chuanlong;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
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antiangiogenesis  curcumin analogs  hypoxia-inducible factor-1 alpha  human umbilical vein endothelial cells  vascular endothelial growth factor  
Rapid transition from continental breakup to igneous oceanic crust in the South China Sea 期刊论文
NATURE GEOSCIENCE, 2018, 卷号: 11, 期号: 10, 页码: 782-+
Authors:  Larsen, H. C.;  Mohn, G.;  Nirrengarten, M.;  Sun, Z.;  Stock, J.;  Jian, Z.;  Klaus, A.;  Alvarez-Zarikian, C. A.;  Boaga, J.;  Bowden, S. A.;  Briais, A.;  Chen, Y.;  Cukur, D.;  Dadd, K.;  Ding, W.;  Dorais, M.;  Ferre, E. C.;  Ferreira, F.;  Furusawa, A.;  Gewecke, A.;  Hinojosa, J.;  Hofig, T. W.;  Hsiung, K. H.;  Huang, B.;  Huang, E.;  Huang, X. L.;  Jiang, S.;  Jin, H.;  Johnson, B. G.;  Kurzawski, R. M.;  Lei, C.;  Li, B.;  Li, L.;  Li, Y.;  Lin, J.;  Liu, C.;  Liu, Z.;  Luna, A. J.;  Lupi, C.;  McCarthy, A.;  Ningthoujam, L.;  Osono, N.;  Peate, D. W.;  Persaud, P.;  Qiu, N.;  Robinson, C.;  Satolli, S.;  Sauermilch, I;  Schindlbeck, J. C.;  Skinner, S.;  Straub, S.;  Su, X.;  Su, C.;  Tian, L.;  Van Der Zwan, F. M.;  Wan, S.;  Wu, H.;  Xiang, R.;  Yadav, R.;  Yi, L.;  Yu, P. S.;  Zhang, C.;  Zhang, J.;  Zhang, Y.;  Zhao, N.;  Zhong, G.;  Zhong, L.
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Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
Authors:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Guo, Shu-Ju;  Li, Xiang-Qian;  Chen, Xue-Chun;  Luo, Jiao;  Li, Chao;  Wang, Yi;  Shi, Da-Yong
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Pyrimidinedionederivatives  DPP-4 inhibitor  Molecular hybrid  SARs  Type 2 diabetes  
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 145-157
Authors:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Li, Xiang-qian;  Guo, Chuan-long;  Guo, Shu-ju;  Shi, Da-Yong
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DPP-4  Inhibitors  Analogs  Physico-chemical properties  SARs  Type 2 diabetes