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Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity
Li, Huili1,2,3; Sun, Boguang1,2; Jiang, Shuai1,2; Sun, Li1,2,3
2021-08-01
Source PublicationBIOMOLECULES
Volume11Issue:8Pages:16
Corresponding AuthorSun, Li(lsun@qdio.ac.cn)
AbstractEdwardsiella tarda is a Gram-negative bacterial pathogen with a broad range of hosts, including fish and mammals. In the present study, we used an advanced antibody array technology to identify the expression pattern of cytokines induced by E. tarda in a mouse infection model. In total, 31 and 24 differentially expressed cytokines (DECs) were identified in the plasma at 6 h and 24 h post-infection (hpi), respectively. The DECs were markedly enriched in the Gene Ontology (GO) terms associated with cell migration and response to chemokine and in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with immunity, diseases, and infection. Ten key DECs, including IL6 and TNF-alpha , were found to form extensive protein-protein interaction networks. IL6 was demonstrated to inhibit E. tarda infection and be required for E. tarda-induced inflammatory response. TNF-alpha also exerted an inhibitory effect on E. tarda infection, and knockdown of fish (Japanese flounder) TNF-alpha promoted E. tarda invasion in host cells. Together, the results of this study revealed a comprehensive profile of cytokines induced by E. tarda, thus adding new insights into the role of cytokine-associated immunity against bacterial infection and also providing the potential plasma biomarkers of E. tarda infection for future studies.
Keywordcytokine Edwardsiella tarda infection antibody array immune response
DOI10.3390/biom11081242
Indexed BySCI
Language英语
Funding Projectgrants of the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ0302-2] ; National Key R&D Program of China[2018YFD0900500] ; Youth Innovation Promotion Association CAS[2021204] ; Taishan Scholar Program of Shandong Province
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000688909800001
PublisherMDPI
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Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/176234
Collection实验海洋生物学重点实验室
Corresponding AuthorSun, Li
Affiliation1.Chinese Acad Sci, CAS Key Lab Expt Marine Biol, Inst Oceanol, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
First Author AffilicationCenter for Ocean Mega-Science, Chinese Academy of Sciences
Corresponding Author AffilicationCenter for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Huili,Sun, Boguang,Jiang, Shuai,et al. Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity[J]. BIOMOLECULES,2021,11(8):16.
APA Li, Huili,Sun, Boguang,Jiang, Shuai,&Sun, Li.(2021).Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity.BIOMOLECULES,11(8),16.
MLA Li, Huili,et al."Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity".BIOMOLECULES 11.8(2021):16.
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