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Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 160, 页码: 496-505
Authors:  Wang, Jun;  Wang, Lijun;  Zhang, Shuhong;  Fan, Junting;  Yang, Hui;  Li, Qiqi;  Guo, Chuanlong
Favorite  |  View/Download:11/0  |  Submit date:2020/10/26
eIF4E/eIF4G  Human lung cancer  Apoptosis  DNA damage  ROS  
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
Authors:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  Favorite  |  View/Download:20/0  |  Submit date:2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
The development of a new real-time subsurface mooring 期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2020, 页码: 12
Authors:  Wang, Fan;  Wang, Jianing;  Xu, Lijun;  Zhang, Xiangguang;  Yan, Shefeng;  Chen, Yonghua
Adobe PDF(8237Kb)  |  Favorite  |  View/Download:11/0  |  Submit date:2020/09/25
real-time subsurface mooring  underwater acoustic communication  Western Pacific  ocean and climate predictions  
BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 150, 页码: 238-245
Authors:  Guo, Chuanlong;  Zhang, Fan;  Wu, Xiaochen;  Yu, Xuemin;  Wu, Xianggen;  Shi, Dayong;  Wang, Lijun
Adobe PDF(1767Kb)  |  Favorite  |  View/Download:3/0  |  Submit date:2020/09/23
PARP-1 inhibitor  DNA double-strand breaks  HCC-1937  In vivo  Apoptosis  
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study 期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
Authors:  Li, Xiuxue;  Wang, Lijun;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Chao;  Zhang, Jiajia;  Shi, Dayong
Adobe PDF(579Kb)  |  Favorite  |  View/Download:2/0  |  Submit date:2020/09/23
Novel compound  Quantitation  UHPLC-TOF-MS  Pharmacokinetics  
The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2020, 卷号: 137, 页码: 10
Authors:  Guo, Chuanlong;  Hou, Yuzhen;  Yu, Xuemin;  Zhang, Fan;  Wu, Xiaochen;  Wu, Xianggen;  Wang, Lijun
Favorite  |  View/Download:2/0  |  Submit date:2020/09/22
Apoptosis  eIF4F  ERK  MNK  A549 cells  
Effects of a natural PTP1B inhibitor from Rhodomela confervoides on the amelioration of fatty acid-induced insulin resistance in hepatocytes and hyperglycaemia in STZ-induced diabetic rats 期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 6, 页码: 3429-3437
Authors:  Guo, Shuju;  Wang, Lijun;  Chen, Dong;  Jiang, Bo
Adobe PDF(699Kb)  |  Favorite  |  View/Download:29/0  |  Submit date:2020/03/20
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
Authors:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  Favorite  |  View/Download:45/0  |  Submit date:2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 17
Authors:  Su, Jingqian;  Guo, Kai;  Huang, Min;  Liu, Yixuan;  Zhang, Jie;  Sun, Lijun;  Li, Daliang;  Pang, Ka-Lai;  Wang, Guangce;  Chen, Long;  Liu, Zhiyu;  Chen, Youqiang;  Chen, Qi;  Huang, Luqiang
Adobe PDF(4000Kb)  |  Favorite  |  View/Download:36/0  |  Submit date:2020/01/03
fucoxanthin  lipopolysaccharide  nuclear factor-kappa B  sepsis  Conticribra weissflogii  
Chalcone-analogue fluorescent probes for detecting thiophenols in seawater samples 期刊论文
TALANTA, 2019, 卷号: 201, 页码: 301-308
Authors:  Liu, Hua;  Guo, Chuanlong;  Guo, Shuju;  Fan, Junting;  Wang, Lijun;  Shi, Dayong
Adobe PDF(1820Kb)  |  Favorite  |  View/Download:41/0  |  Submit date:2019/08/29
Fluorescent probe  Thiophenol  Seawater sample  Chalcone