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A novel fluorinated thiosemicarbazone derivative-2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 491, 期号: 1, 页码: 65-71
作者:  Zhao, Yue;  Guo, Chuanlong;  Wang, Lijun;  Wang, Shuaiyu;  Li, Xiangqian;  Jiang, Bo;  Wu, Ning;  Guo, Shuju;  Zhang, Renshuai;  Liu, Kun;  Shi, Dayong
Adobe PDF(1849Kb)  |  收藏  |  浏览/下载：337/0  |  提交时间：2018/01/11
Thiosemicarbazone  Anticancer  2-(3  Apoptosis  4-difluorobenzylidene) Hydrazinecarbothioamide  Ros  Mitochondria-dependent Pathway  
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 134, 页码: 24-33
作者:  Zhang, Renshuai;  Yu, Rilei;  Xu, Qi;  Li, Xiangqian;  Luo, Jiao;  Jiang, Bo;  Wang, Lijun;  Guo, Shuju;  Wu, Ning;  Shi, Dayong
Adobe PDF(3126Kb)  |  收藏  |  浏览/下载：253/0  |  提交时间：2017/07/10
Ptp1b  Bromophenol  Saccharide  Selectivity  Permeability  
Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 11, 页码: 2488-2492
作者:  Zhang, Renshuai;  Song, Lairong;  Jiang, Bo;  Wang, Lijun;  Wu, Ning;  Guo, Shuju;  Shi, Dayong
Adobe PDF(1892Kb)  |  收藏  |  浏览/下载：214/0  |  提交时间：2017/09/30
Saccharide  Glut1  Drug Design  Anticancer  Cell Uptake  
The design strategy of selective PTP1B inhibitors over TCPTP 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 16, 页码: 3343-3352
作者:  Li, XiangQian;  Wang, LiJun;  Shi, DaYong
Adobe PDF(2312Kb)  |  收藏  |  浏览/下载：192/1  |  提交时间：2016/12/05
Selectivity  Ptp1b Inhibitor  Tcptp  Diabetes  Design Strategy  
Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells 期刊论文
TUMOR BIOLOGY, 2015, 卷号: 36, 期号: 12, 页码: 9667-9676
作者:  Wu, Ning;  Liu, Jia;  Zhao, Xiangzhong;  Yan, Zhiyong;  Jiang, Bo;  Wang, Lijun;  Cao, Shousong;  Shi, Dayong;  Lin, Xiukun
Adobe PDF(1959Kb)  |  收藏  |  浏览/下载：249/1  |  提交时间：2016/02/05
Cardamonin  Glioblastoma Stem Cell  Stat3  Apoptosis  Temozolomide  Self-renewal  
Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 7, 页码: 4452-4469
作者:  Luo, Jiao;  Wu, Ning;  Jiang, Bo;  Wang, Lijun;  Wang, Shuaiyu;  Li, Xiangqian;  Wang, Baocheng;  Wang, Changhui;  Shi, Dayong
Adobe PDF(1638Kb)  |  收藏  |  浏览/下载：254/2  |  提交时间：2015/12/07
Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating beta 1-Integrin/FAK Signaling 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 2, 页码: 1010-1025
作者:  Wu, Ning;  Luo, Jiao;  Jiang, Bo;  Wang, Lijun;  Wang, Shuaiyu;  Wang, Changhui;  Fu, Changqing;  Li, Jian;  Shi, Dayong
Adobe PDF(995Kb)  |  收藏  |  浏览/下载：226/1  |  提交时间：2015/06/15
Genome-wide and single-base resolution DNA methylomes of the Pacific oyster Crassostrea gigas provide insight into the evolution of invertebrate CpG methylation 期刊论文
BMC GENOMICS, 2014, 卷号: 15, 页码: 1119
作者:  Wang, Xiaotong;  Li, Qiye;  Lian, Jinmin;  Li, Li;  Jin, Lijun;  Cai, Huimin;  Xu, Fei;  Qi, Haigang;  Zhang, Linlin;  Wu, Fucun;  Meng, Jie;  Que, Huayong;  Fang, Xiaodong;  Guo, Ximing;  Zhang, Guofan;  Guo, XM (reprint author), Rutgers State Univ, Inst Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ 08349 USA.
Adobe PDF(1086Kb)  |  收藏  |  浏览/下载：364/1  |  提交时间：2015/06/11
Mollusca  Oyster  Crassostrea Gigas  Dna Methylation  Genome-wide  Gene Age  
Isolation and Characterization of Fucoidans from Five Brown Algae and Evaluation of Their Antioxidant Activity 期刊论文
JOURNAL OF OCEAN UNIVERSITY OF CHINA, 2014, 卷号: 13, 期号: 5, 页码: 851-856
作者:  Qu Guiyan;  Liu Xu;  Wang Dongfeng;  Yuan Yi;  Han Lijun;  Han, LJ (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
Adobe PDF(364Kb)  |  收藏  |  浏览/下载：230/0  |  提交时间：2015/06/11
Fucoidans Composition  Antioxidant Property  Laminaria Japonica  Lessonia Nigrescens  Lessonia Trabeculata  Ascophyllum Mackaii  Ecklonia Maxima  
一种夏鲆精子便捷式超低温冷冻方法 专利
专利类型: 发明, 专利号: CN201310214338.2, 申请日期: 2013-09-25, 公开日期: 2013-09-25
发明人:  刘清华;  李军;  王文琪;  徐世宏;  韩龙江
Adobe PDF(349Kb)  |  收藏  |  浏览/下载：239/1  |  提交时间：2014/08/04
一种夏鲆精子便捷式超低温冷冻方法  其特征在于：1）冷冻保存：将活力高于85%的夏鲆精子与抗冻液以1:3‑1:2的体积比混合  2）解冻：将上述冻存冻精于亲鱼车间的循环水中即可解冻  混合后置于容器内再一并移入液氮罐内进行一步预冷  待冻精由固态融化为液态置于0‑4℃冰箱中保存备用。  两步冷冻  而后投入液氮中进行长期保存