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BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
Authors:  Guo, Chuanlong;  Wang, Lijun;  Zhao, Yue;  Jiang, Bo;  Luo, Jiao;  Shi, Dayong
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bromophenol  apoptosis  autophagy  phosphoinositide 3-kinase  protein kinase B  mechanistic target of rapamycin signaling  reactive oxygen species  
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2 ',3,3 '-Tetrabromo-4,4 ',5,5 '-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice 期刊论文
MOLECULAR PHARMACEUTICS, 2019, 卷号: 16, 期号: 5, 页码: 1839-1850
Authors:  Li, Chao;  Luo, Jiao;  Guo, Shuju;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Xiangqian;  Xu, Qi;  Shi, Dayong
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type 2 diabetes mellitus  protein tyrosine phosphatase 1B  insulin resistance  hypoglycemic activity  dyslipidemia  
Discovery of Novel Bromophenol Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3051-3067
Authors:  Guo, Chuanlong;  Wang, Lijun;  Li, Xinxue;  Wang, Shuaiyu;  Yu, Xuemin;  Xu, Kuo;  Zhao, Yue;  Luo, Jiao;  Li, Xiangqian;  Jiang, Bo;  Shi, Dayong
Favorite  |  View/Download:3/0  |  Submit date:2019/08/28
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
Authors:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
Favorite  |  View/Download:13/0  |  Submit date:2019/05/15
Anti-diabetic  PTP1B inhibitor  Selectivity  BKS db mice  Toxicity  
CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 15
Authors:  Luo, Jiao;  Jiang, Bo;  Li, Chao;  Jia, Xiaoling;  Shi, Dayong
Favorite  |  View/Download:3/0  |  Submit date:2019/08/28
brominated organic compounds  hypoglycemic activity  insulin-sensitizing effect  RBPs  RNA splicing  
Carbon pools and fluxes in the China Seas and adjacent oceans 期刊论文
SCIENCE CHINA-EARTH SCIENCES, 2018, 卷号: 61, 期号: 11, 页码: 1535-1563
Authors:  Jiao, Nianzhi;  Liang, Yantao;  Zhang, Yongyu;  Liu, Jihua;  Zhang, Yao;  Zhang, Rui;  Zhao, Meixun;  Dai, Minhan;  Zhai, Weidong;  Gao, Kunshan;  Song, Jinming;  Yuan, Dongliang;  Li, Chao;  Lin, Guanghui;  Huang, Xiaoping;  Yan, Hongqiang;  Hu, Limin;  Zhang, Zenghu;  Wang, Long;  Cao, Chunjie;  Luo, Yawei;  Luo, Tingwei;  Wang, Nannan;  Dang, Hongyue;  Wang, Dongxiao;  Zhang, Si
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China Seas  "Source" or "sink" of CO2  Carbon pool  Carbon flux  Biological pump  Microbial carbon pump  
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
Authors:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Guo, Shu-Ju;  Li, Xiang-Qian;  Chen, Xue-Chun;  Luo, Jiao;  Li, Chao;  Wang, Yi;  Shi, Da-Yong
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Pyrimidinedionederivatives  DPP-4 inhibitor  Molecular hybrid  SARs  Type 2 diabetes  
靶向PTP1B海洋溴代化合物的降糖作用研究 学位论文
理学博士, 中国科学院海洋研究所: 中国科学院大学, 2018
Authors:  罗娇
Adobe PDF(54039Kb)  |  Favorite  |  View/Download:52/2  |  Submit date:2018/05/30
海洋溴代化合物,ptp1b抑制剂,选择性,膜通透性,降糖作用  
Direct Electrochemical Vibrio DNA Sensing Adopting Highly Stable Graphene-Flavin Mononucleotide Aqueous Dispersion Modified Interface 期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2018, 卷号: 10, 期号: 5, 页码: 4540-4547
Authors:  Yang, Tao;  Chen, Huaiyin;  Qiu, Zhiwei;  Yu, Renzhong;  Luo, Shizhong;  Li, Weihua;  Jiao, Kui
Adobe PDF(5776Kb)  |  Favorite  |  View/Download:78/0  |  Submit date:2018/04/02
Graphene  Flavin Mononucleotide  Graphene Aqueous Dispersion  Self-signal  Dna Sensing  
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway 期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 2, 页码: 13
Authors:  Guo, Chuan-Long;  Wang, Li-Jun;  Zhao, Yue;  Liu, Hua;  Li, Xiang-Qian;  Jiang, Bo;  Luo, Jiao;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
Adobe PDF(5208Kb)  |  Favorite  |  View/Download:0/0  |  Submit date:2019/08/21
bromophenol  molecular mechanisms  apoptosis  cell cycle  PI3K  Akt  p38  ERK  ROS  human lung cancer