Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway

doi:10.1016/j.fct.2023.113844

IOCAS-IR > 实验海洋生物学重点实验室

	Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway
	Liu, Shuai 1; Gao, Xintao 1; Yin, Yulan 1; Wang, Jing2 ; Dong, Kehong 1; Shi, Dayong 3; Wu, Xiaochen 1; Guo, Chuanlong 1,3,4
	2023-07-01
发表期刊	FOOD AND CHEMICAL TOXICOLOGY
ISSN	0278-6915
卷号	177 页码:10
通讯作者	Guo, Chuanlong(guochuanlong@qust.edu.cn)
摘要	Silk fibroin (SF) has excellent biocompatibility and biodegradability as a biomaterial. The purity and molecular weight distribution of silk fibroin peptide (SFP) make it more suitable for medical application. In this study, SFP nanofibers (molecular weight similar to 30kD) were prepared through CaCl2/H2O/C2H5OH solution decomposition and dialysis, and adsorbed naringenin (NGN) to obtain SFP/NGN NFs. In vitro results showed that SFP/NGN NFs increased the antioxidant activity of NGN and protected HK-2 cells from cisplatin-induced damage. In vivo results also showed that SFP/NGN NFs protected mice from cisplatin-induced acute kidney injury (AKI). The mechanism results showed that cisplatin induced mitochondrial damage, as well as increased mitophagy and mtDNA release, which activated the cGAS-STING pathway and induced the expression of inflammatory factors such as IL-6 and TNF-alpha. Interestingly, SFP/NGN NFs further activated mitophagy and inhibited mtDNA release and cGAS-STING pathway. Demonstrated that mitophagy-mtDNA-cGAS-STING signal axis was involved in the kidney protection mechanism of SFP/NGN NFs. In conclusion, our study confirmed that SFP/NGN NFs are candidates for protection of cisplatin-induced AKI, which is worthy of further study.
关键词	Silk fibroin peptide Naringin Acute kidney injury Mitophagy cGAS-STING pathway
DOI	10.1016/j.fct.2023.113844
收录类别	SCI
语种	英语
资助项目	Shandong Provincial Natural Science Foundation[ZR2020QH359] ; Open Fund of CAS ; Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06] ; State Key Laboratory of Microbial Technology Open Projects Fund[M2021-14] ; Program for Young Talents of Science and Technology in Universities of Inner Mongolia[NJYT-18-B29] ; Doctoral Scientific Research Foundation of Inner Mongolia[BTTCRCQD2018001]
WOS研究方向	Food Science & Technology ; Toxicology
WOS类目	Food Science & Technology ; Toxicology
WOS记录号	WOS:001010725500001
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	INFLAMMATION ; DNA ; MECHANISMS ; MITOPHAGY ; APOPTOSIS ; DISEASES
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182431
专题	实验海洋生物学重点实验室
通讯作者	Guo, Chuanlong
作者单位	1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Baotou Teachers Coll, Dept Biol Sci & Technol, Baotou 014030, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266273, Shandong, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Shuai,Gao, Xintao,Yin, Yulan,et al. Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway[J]. FOOD AND CHEMICAL TOXICOLOGY,2023,177:10.
APA	Liu, Shuai.,Gao, Xintao.,Yin, Yulan.,Wang, Jing.,Dong, Kehong.,...&Guo, Chuanlong.(2023).Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.FOOD AND CHEMICAL TOXICOLOGY,177,10.
MLA	Liu, Shuai,et al."Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway".FOOD AND CHEMICAL TOXICOLOGY 177(2023):10.