The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction

doi:10.3390/ijms21031038

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	The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction
	Zhang, Jiajia1,2,3 ; Dai, Jiajia 4; Zheng, Qingxuan 4; Guo, Shuju 1,2,3; Yu, Yanyan 4; Hu, Wenpeng 4; Gao, Yanan 4; Shi, Dayong 1,2,3,4
	2020-02-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	21 期号:3 页码:15
通讯作者	Shi, Dayong(shidayong@sdu.edu.cn)
摘要	Triple negative breast cancer (TNBC) is the most aggressive cancer in women, and despite improved treatments, it remains a major cause of morbidity and mortality. We and others have demonstrated that different hybrid compounds targeting PARP/MAPK or other pathways to inhibit cancer progression may lead to promising therapeutic results. We introduced fluorine to alter the physical properties of the compounds. TSC-3C was one of the generated compounds. Upon treatment with TSC-3C, MDA-MB-231 cell proliferation, invasion, and migration were inhibited. TSC-3C induced MDA-MB-231 cell mitochondrial dysfunction and apoptosis, which may be caused by reducing the level of phosphorylated p44/42 MAPK (ERK1/2) and increasing the level of p-JNK. The present study may help to elucidate the role of the MAPK pathway in the development of breast cancer and may promote further research on halogenated heterocyclic compounds for the treatment of breast cancer.
关键词	triple negative breast cancer MDA-MB-231 cells fluoro-thiazolylhydrazone MAPK pathway phosphorylated p44/42 MAPK (ERK1/2) phosphorylated c-Jun N-terminal kinase (p-JNK) apoptosis
DOI	10.3390/ijms21031038
收录类别	SCI
语种	英语
资助项目	NSFC-Shandong Joint Fund[U1706213] ; Sub-Class of Project of the National Natural Science Foundation of China[81803375] ; Surface Project of the National Natural Science Foundation of China[81773586] ; Surface Project of the National Natural Science Foundation of China[81872906] ; Sub-Class Project of the National Natural Science Foundation of China[81903354]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000522551606024
出版者	MDPI
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/167269
专题	实验海洋生物学重点实验室
通讯作者	Shi, Dayong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 10049, Peoples R China 4.Shandong Univ, Inst Microbial Technol, State Key Lab Microbial Technol, Jinan 250014, Peoples R China
第一作者单位	实验海洋生物学重点实验室
通讯作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Zhang, Jiajia,Dai, Jiajia,Zheng, Qingxuan,et al. The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(3):15.
APA	Zhang, Jiajia.,Dai, Jiajia.,Zheng, Qingxuan.,Guo, Shuju.,Yu, Yanyan.,...&Shi, Dayong.(2020).The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(3),15.
MLA	Zhang, Jiajia,et al."The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.3(2020):15.

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