Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

doi:10.1016/j.carbpol.2020.116002

IOCAS-IR > 实验海洋生物学重点实验室

	Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications
	Qin, Yukun 1,2; Li, Pengcheng1,2 ; Guo, Zhanyong 3
	2020-05-15
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	236 页码:17
通讯作者	Li, Pengcheng(pcli@qdio.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
摘要	The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.
关键词	Cationic chitosan derivatives Antifungals Structural optimization strategy Antifungal therapy
DOI	10.1016/j.carbpol.2020.116002
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFC0311305] ; National Key R&D Program of China[2019YFD0900705] ; Key Research and Development Program of Shandong Province[2018GHY115017] ; Qingdao Applied Basic Research Project[19-6-2-34-cg] ; Science and technology program of Nantong[MS120170234]
WOS研究方向	Chemistry ; Polymer Science
WOS类目	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000519306900012
出版者	ELSEVIER SCI LTD
引用统计	被引频次：99[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/165871
专题	实验海洋生物学重点实验室
通讯作者	Li, Pengcheng; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Qin, Yukun,Li, Pengcheng,Guo, Zhanyong. Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications[J]. CARBOHYDRATE POLYMERS,2020,236:17.
APA	Qin, Yukun,Li, Pengcheng,&Guo, Zhanyong.(2020).Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications.CARBOHYDRATE POLYMERS,236,17.
MLA	Qin, Yukun,et al."Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications".CARBOHYDRATE POLYMERS 236(2020):17.

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Cationic chitosan de（1903KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览