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Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 15
作者:  Xu, Qi;  Wu, Ning;  Li, Xiangqian;  Guo, Chuanlong;  Li, Chao;  Jiang, Bo;  Wang, Huaizhi;  Shi, Dayong
Adobe PDF(3632Kb)  |  收藏  |  浏览/下载：345/0  |  提交时间：2020/03/20
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  收藏  |  浏览/下载：370/0  |  提交时间：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS  
BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 17, 期号: 5, 页码: 3848-3858
作者:  Guo, Chuanlong;  Wang, Lijun;  Zhao, Yue;  Jiang, Bo;  Luo, Jiao;  Shi, Dayong
Adobe PDF(2683Kb)  |  收藏  |  浏览/下载：279/0  |  提交时间：2019/08/28
bromophenol  apoptosis  autophagy  phosphoinositide 3-kinase  protein kinase B  mechanistic target of rapamycin signaling  reactive oxygen species  
Discovery of Novel Bromophenol Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3051-3067
作者:  Guo, Chuanlong;  Wang, Lijun;  Li, Xinxue;  Wang, Shuaiyu;  Yu, Xuemin;  Xu, Kuo;  Zhao, Yue;  Luo, Jiao;  Li, Xiangqian;  Jiang, Bo;  Shi, Dayong
Adobe PDF(8824Kb)  |  收藏  |  浏览/下载：391/0  |  提交时间：2019/08/28
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
作者:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
Adobe PDF(2321Kb)  |  收藏  |  浏览/下载：215/0  |  提交时间：2019/05/15
Anti-diabetic  PTP1B inhibitor  Selectivity  BKS db mice  Toxicity  
Mid-late Holocene rainfall variation in Taiwan: A high-resolution multi proxy record unravels the dual influence of the Asian monsoon and ENSO 期刊论文
PALAEOGEOGRAPHY PALAEOCLIMATOLOGY PALAEOECOLOGY, 2019, 卷号: 516, 页码: 139-151
作者:  Chen, Jinxia;  Li, Tiegang;  Nan, Qingyun;  Shi, Xuefa;  Liu, Yanguang;  Jiang, Bo;  Zou, Jianjun;  Selvaraj, Kandasamy;  Li, Dongling;  Li, Chuanshun
Adobe PDF(1763Kb)  |  收藏  |  浏览/下载：316/0  |  提交时间：2019/08/27
Fern spore  C/N ratio  La Nina  Tropical cyclone  Okinawa Trough  
CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 15
作者:  Luo, Jiao;  Jiang, Bo;  Li, Chao;  Jia, Xiaoling;  Shi, Dayong
收藏  |  浏览/下载：348/0  |  提交时间：2019/08/28
brominated organic compounds  hypoglycemic activity  insulin-sensitizing effect  RBPs  RNA splicing  
中国物理海洋学研究70年发展历程学术成就概览 期刊论文
海洋学报, 2019, 卷号: 41, 期号: 10, 页码: 23
作者:  魏泽勋;  郑全安;  杨永增;  刘克修;  徐腾飞;  王凡;  胡石建;  谢玲玲;  李元龙;  杜岩;  周磊;  林霄沛;  胡建宇;  朱建荣;  李均益;  张正光;  侯一筠;  刘泽;  田纪伟;  黄晓冬;  管玉平;  刘志宇;  杨庆轩;  赵玮;  宋振亚;  刘海龙;  董昌明;  于卫东;  连涛;  陈朝晖;  史久新;  雷瑞波;  刘煜;  于福江;  尹宝树;  陈戈;  王岩峰;  李整林;  熊学军;  汪嘉宁;  李晓峰;  王永刚
收藏  |  浏览/下载：717/0  |  提交时间：2020/01/03