CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs

doi:10.3390/md17010049

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	CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs
	Luo, Jiao 1,2; Jiang, Bo 2; Li, Chao 2; Jia, Xiaoling 2; Shi, Dayong 3
	2019
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	17 期号:1 页码:15
通讯作者	Shi, Dayong(shidayong@sdu.edu.cn)
摘要	RNA-binding proteins (RBPs) lie at the center of posttranscriptional regulation and the dysregulation of RBPs contributes to diabetes. Therefore, the modulation of RBPs is anticipated to become a potential therapeutic approach to diabetes. CYC27 is a synthetic derivative of marine bromophenol BDB, which is isolated from red alga Rhodomela confervoides. In this study, we found that CYC27 significantly lowered the blood glucose levels of diabetic BKS db mice. Moreover, CYC27 effectively ameliorated dyslipidemia in BKS db mice by reducing their total serum cholesterol (TC) and triglyceride (TG) levels. Furthermore, CYC27 was an insulin-sensitizing agent with increased insulin-stimulated phosphorylation of insulin receptors and relevant downstream factors. Finally, to systemically study the mechanisms of CYC27, label-free quantitative phosphoproteomic analysis was performed to investigate global changes in phosphorylation. Enriched GO annotation showed that most regulated phosphoproteins were related to RNA splicing and RNA processing. Enriched KEGG analysis showed that a spliceosome-associated pathway was the predominant pathway after CYC27 treatment. Protein-protein interaction (PPI) analysis showed that CYC27 modulated the process of mRNA splicing via phosphorylation of the relevant RBPs, including upregulated Cstf3 and Srrt. Our results suggested that CYC27 treatment exerted promising anti-diabetic effects by sensitizing the insulin signaling pathways and modulating RNA splicing-associated RBPs.
关键词	brominated organic compounds hypoglycemic activity insulin-sensitizing effect RBPs RNA splicing
DOI	10.3390/md17010049
收录类别	SCI
语种	英语
资助项目	Key Research and Development Project of the Shandong Province[2018GSF118208] ; Key Research and Development Project of the Shandong Province[2016ZDJS07A13] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; National Program for Support of Top-notch Young Professionals ; Fund of Taishan Scholar Project ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; NSFC-Shandong Joint Fund[U1706213] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-1-1] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-3-9] ; Key Research and Development Project of the Shandong Province[2018GSF118208] ; Key Research and Development Project of the Shandong Province[2016ZDJS07A13] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; National Program for Support of Top-notch Young Professionals ; Fund of Taishan Scholar Project ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; NSFC-Shandong Joint Fund[U1706213] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-1-1] ; Qingdao Marine Biomedical Science and Technology Innovation Center Project[2017-CXZX01-3-9]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000458053200049
出版者	MDPI
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/160871
专题	实验海洋生物学重点实验室
通讯作者	Shi, Dayong
作者单位	1.Qingdao Univ, Sch Publ Hlth, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Luo, Jiao,Jiang, Bo,Li, Chao,et al. CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs[J]. MARINE DRUGS,2019,17(1):15.
APA	Luo, Jiao,Jiang, Bo,Li, Chao,Jia, Xiaoling,&Shi, Dayong.(2019).CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs.MARINE DRUGS,17(1),15.
MLA	Luo, Jiao,et al."CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs".MARINE DRUGS 17.1(2019):15.