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Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 13
作者:  Jiang, Bo;  Luo, Jiao;  Guo, Shuju;  Wang, Lijun
Adobe PDF(8153Kb)  |  收藏  |  浏览/下载：206/0  |  提交时间：2021/05/11
Type 2 diabetes mellitus  Protein tyrosine phosphatase 1B inhibitors  Thiazolidinedione  Insulin signaling  Anti-diabetic activities  
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:  Luo, Jiao;  Zheng, Meiling;  Jiang, Bo;  Li, Chao;  Guo, Shuju;  Wang, Lijun;  Li, Xiangqian;  Yu, Rilei;  Shi, Dayong
Adobe PDF(42653Kb)  |  收藏  |  浏览/下载：337/0  |  提交时间：2020/09/29
bromophenol  PTP1B inhibitor  selectivity  cell permeability  oral bioavailability  
CYC27 Synthetic Derivative of Bromophenol from Red Alga Rhodomela confervoides: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs 期刊论文
MARINE DRUGS, 2019, 卷号: 17, 期号: 1, 页码: 15
作者:  Luo, Jiao;  Jiang, Bo;  Li, Chao;  Jia, Xiaoling;  Shi, Dayong
收藏  |  浏览/下载：347/0  |  提交时间：2019/08/28
brominated organic compounds  hypoglycemic activity  insulin-sensitizing effect  RBPs  RNA splicing  
BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 卷号: 106, 页码: 379-386
作者:  Xu, Qi;  Luo, Jiao;  Wu, Ning;  Zhang, Renshuai;  Shi, Dayong
Adobe PDF(1900Kb)  |  收藏  |  浏览/下载：236/0  |  提交时间：2018/04/02
Bpn  Protein Tyrosine Phosphatase 1b  Insulin Signaling  Insulin Resistance  C2c12 Myotubes  
The Hot and Potential Targets of Type 2 Diabetes Mellitus Treatment in Recent Decade 期刊论文
CURRENT DRUG TARGETS, 2018, 卷号: 19, 期号: 1, 页码: 55-69
作者:  Xu, Qi;  Wang, Lijun;  Luo, Jiao;  Shi, Dayong
Adobe PDF(2267Kb)  |  收藏  |  浏览/下载：219/0  |  提交时间：2018/04/02
Type 2 Diabetes Mellitus  Insulin Resistance  Insulin Secretion  Targets  Mechanism  Drugs  
The Evaluation and Utilization of Marine-derived Bioactive Compounds with Anti-Obesity Effect 期刊论文
CURRENT MEDICINAL CHEMISTRY, 2018, 卷号: 25, 期号: 7, 页码: 861-878
作者:  Jin, Qiu;  Yu, Huahua;  Li, Pengcheng
Adobe PDF(757Kb)  |  收藏  |  浏览/下载：296/0  |  提交时间：2019/08/21
Anti-obesity  marine-derived  digestive enzyme  appetite  fat absorption  adipogenesis  thermogenesis  utilization  
Antidiabetic Activity of Differently Regioselective Chitosan Sulfates in Alloxan-Induced Diabetic Rats 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 5, 页码: 3072-3090
作者:  Xing, Ronge;  He, Xiaofei;  Liu, Song;  Yu, Huahua;  Qin, Yukun;  Chen, Xiaolin;  Li, Kecheng;  Li, Rongfeng;  Li, Pengcheng
Adobe PDF(919Kb)  |  收藏  |  浏览/下载：335/0  |  提交时间：2015/07/27
Differently Regioselective Chitosan Sulfates  Hypoglycemic Activity  Glucose Tolerance  Plasma Insulin  Alloxan-induced Diabetic Rats  
Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism 期刊论文
CARBOHYDRATE POLYMERS, 2013, 卷号: 95, 期号: 1, 页码: 143-147
作者:  Wang, Jing;  Jin, Weihua;  Zhang, Wenjing;  Hou, Yun;  Zhang, Hong;  Zhang, Quanbin;  Zhang, QB
Adobe PDF(369Kb)  |  收藏  |  浏览/下载：283/0  |  提交时间：2014/07/17
Sulfated Polysaccharide  Hypoglycemic  Mechanism