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Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism
Wang, Jing1,3; Jin, Weihua1,2,3; Zhang, Wenjing2,3; Hou, Yun2,3; Zhang, Hong3; Zhang, Quanbin3; Zhang, QB
2013-05-05
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume95Issue:1Pages:143-147
SubtypeArticle
AbstractIn the present study, a sulfated polysaccharide fucoidan extracted from Saccharina japonica was administered to normal and alloxan-diabetic rats/mice, and its effects on glycemia, insulin and serum lipid levels were evaluated. Fucoidan administered at 200 or 1200 mg/kg body weight/day could significantly reduce the blood glucose level by 22% and 34%, respectively, in alloxan-induced diabetic rats. Serum insulin levels in diabetic mice were increased by the administration of fucoidan (P<0.05). The results of an oral glucose tolerance test (OGTT) revealed that fucoidan treatment had some effect on glucose disposal after 15 days of treatment. Furthermore, fucoidan altered plasma lipid levels by lowering cholesterol, triglyceride and plasma low-density lipoprotein concentrations, while elevating plasma high-density lipoprotein cholesterol at 100 or 300 mg/kg body weight/day. The results suggested that fucoidan exhibited a considerable hypoglycemic effect, possibly by stimulating pancreatic release of insulin and/or by reducing insulin metabolism. Our results indicated that fucoidan could be developed as a potential oral hypoglycemic agents or functional food for the management of diabetes. (C) 2013 Elsevier Ltd. All rights reserved.; In the present study, a sulfated polysaccharide fucoidan extracted from Saccharina japonica was administered to normal and alloxan-diabetic rats/mice, and its effects on glycemia, insulin and serum lipid levels were evaluated. Fucoidan administered at 200 or 1200 mg/kg body weight/day could significantly reduce the blood glucose level by 22% and 34%, respectively, in alloxan-induced diabetic rats. Serum insulin levels in diabetic mice were increased by the administration of fucoidan (P<0.05). The results of an oral glucose tolerance test (OGTT) revealed that fucoidan treatment had some effect on glucose disposal after 15 days of treatment. Furthermore, fucoidan altered plasma lipid levels by lowering cholesterol, triglyceride and plasma low-density lipoprotein concentrations, while elevating plasma high-density lipoprotein cholesterol at 100 or 300 mg/kg body weight/day. The results suggested that fucoidan exhibited a considerable hypoglycemic effect, possibly by stimulating pancreatic release of insulin and/or by reducing insulin metabolism. Our results indicated that fucoidan could be developed as a potential oral hypoglycemic agents or functional food for the management of diabetes. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordSulfated Polysaccharide Hypoglycemic Mechanism
Subject AreaChemistry ; Polymer Science
DOI10.1016/j.carbpol.2013.02.076
URL查看原文
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000319029700019
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/16705
Collection海洋生物技术研发中心
Corresponding AuthorZhang, QB
Affiliation1.Chinese Acad Sci, Nantong Branch, Inst Oceanol, Nantong 226006, Jiangsu, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Jing,Jin, Weihua,Zhang, Wenjing,et al. Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism[J]. CARBOHYDRATE POLYMERS,2013,95(1):143-147.
APA Wang, Jing.,Jin, Weihua.,Zhang, Wenjing.,Hou, Yun.,Zhang, Hong.,...&Zhang, QB.(2013).Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism.CARBOHYDRATE POLYMERS,95(1),143-147.
MLA Wang, Jing,et al."Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism".CARBOHYDRATE POLYMERS 95.1(2013):143-147.
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