| Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism | |
Wang, Jing1,3 ; Jin, Weihua1,2,3; Zhang, Wenjing2,3; Hou, Yun2,3; Zhang, Hong3; Zhang, Quanbin3; Zhang, QB
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| 2013-05-05 | |
| Source Publication | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| Volume | 95Issue:1Pages:143-147 |
| Subtype | Article |
| Abstract | In the present study, a sulfated polysaccharide fucoidan extracted from Saccharina japonica was administered to normal and alloxan-diabetic rats/mice, and its effects on glycemia, insulin and serum lipid levels were evaluated. Fucoidan administered at 200 or 1200 mg/kg body weight/day could significantly reduce the blood glucose level by 22% and 34%, respectively, in alloxan-induced diabetic rats. Serum insulin levels in diabetic mice were increased by the administration of fucoidan (P<0.05). The results of an oral glucose tolerance test (OGTT) revealed that fucoidan treatment had some effect on glucose disposal after 15 days of treatment. Furthermore, fucoidan altered plasma lipid levels by lowering cholesterol, triglyceride and plasma low-density lipoprotein concentrations, while elevating plasma high-density lipoprotein cholesterol at 100 or 300 mg/kg body weight/day. The results suggested that fucoidan exhibited a considerable hypoglycemic effect, possibly by stimulating pancreatic release of insulin and/or by reducing insulin metabolism. Our results indicated that fucoidan could be developed as a potential oral hypoglycemic agents or functional food for the management of diabetes. (C) 2013 Elsevier Ltd. All rights reserved.; In the present study, a sulfated polysaccharide fucoidan extracted from Saccharina japonica was administered to normal and alloxan-diabetic rats/mice, and its effects on glycemia, insulin and serum lipid levels were evaluated. Fucoidan administered at 200 or 1200 mg/kg body weight/day could significantly reduce the blood glucose level by 22% and 34%, respectively, in alloxan-induced diabetic rats. Serum insulin levels in diabetic mice were increased by the administration of fucoidan (P<0.05). The results of an oral glucose tolerance test (OGTT) revealed that fucoidan treatment had some effect on glucose disposal after 15 days of treatment. Furthermore, fucoidan altered plasma lipid levels by lowering cholesterol, triglyceride and plasma low-density lipoprotein concentrations, while elevating plasma high-density lipoprotein cholesterol at 100 or 300 mg/kg body weight/day. The results suggested that fucoidan exhibited a considerable hypoglycemic effect, possibly by stimulating pancreatic release of insulin and/or by reducing insulin metabolism. Our results indicated that fucoidan could be developed as a potential oral hypoglycemic agents or functional food for the management of diabetes. (C) 2013 Elsevier Ltd. All rights reserved. |
| Keyword | Sulfated Polysaccharide Hypoglycemic Mechanism |
| Subject Area | Chemistry ; Polymer Science |
| DOI | 10.1016/j.carbpol.2013.02.076 |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry ; Polymer Science |
| WOS Subject | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS ID | WOS:000319029700019 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/16705 |
| Collection | 海洋生物技术研发中心 |
| Corresponding Author | Zhang, QB |
| Affiliation | 1.Chinese Acad Sci, Nantong Branch, Inst Oceanol, Nantong 226006, Jiangsu, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Wang, Jing,Jin, Weihua,Zhang, Wenjing,et al. Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism[J]. CARBOHYDRATE POLYMERS,2013,95(1):143-147. |
| APA | Wang, Jing.,Jin, Weihua.,Zhang, Wenjing.,Hou, Yun.,Zhang, Hong.,...&Zhang, QB.(2013).Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism.CARBOHYDRATE POLYMERS,95(1),143-147. |
| MLA | Wang, Jing,et al."Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism".CARBOHYDRATE POLYMERS 95.1(2013):143-147. |
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