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Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 15
作者:  Xu, Qi;  Wu, Ning;  Li, Xiangqian;  Guo, Chuanlong;  Li, Chao;  Jiang, Bo;  Wang, Huaizhi;  Shi, Dayong
Adobe PDF(3632Kb)  |  收藏  |  浏览/下载：305/0  |  提交时间：2020/03/20
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2 ',3,3 '-Tetrabromo-4,4 ',5,5 '-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice 期刊论文
MOLECULAR PHARMACEUTICS, 2019, 卷号: 16, 期号: 5, 页码: 1839-1850
作者:  Li, Chao;  Luo, Jiao;  Guo, Shuju;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Xiangqian;  Xu, Qi;  Shi, Dayong
收藏  |  浏览/下载：324/0  |  提交时间：2019/08/28
type 2 diabetes mellitus  protein tyrosine phosphatase 1B  insulin resistance  hypoglycemic activity  dyslipidemia  
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 178-185
作者:  Li, Xiangqian;  Xu, Qi;  Li, Chao;  Luo, Jiao;  Li, Xiuxue;  Wang, Lijun;  Jiang, Bo;  Shi, Dayong
Adobe PDF(2321Kb)  |  收藏  |  浏览/下载：197/0  |  提交时间：2019/05/15
Anti-diabetic  PTP1B inhibitor  Selectivity  BKS db mice  Toxicity  
Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 卷号: 175, 期号: 1, 页码: 140-153
作者:  Luo, Jiao;  Xu, Qi;  Jiang, Bo;  Zhang, Renshuai;  Jia, Xiaoling;  Li, Xiangqian;  Wang, Lijun;  Guo, Chuanlong;  Wu, Ning;  Shi, Dayong
Adobe PDF(2211Kb)  |  收藏  |  浏览/下载：257/0  |  提交时间：2019/08/20
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 134, 页码: 24-33
作者:  Zhang, Renshuai;  Yu, Rilei;  Xu, Qi;  Li, Xiangqian;  Luo, Jiao;  Jiang, Bo;  Wang, Lijun;  Guo, Shuju;  Wu, Ning;  Shi, Dayong
Adobe PDF(3126Kb)  |  收藏  |  浏览/下载：261/0  |  提交时间：2017/07/10
Ptp1b  Bromophenol  Saccharide  Selectivity  Permeability