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A novel fluorinated thiosemicarbazone derivative-2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 491, 期号: 1, 页码: 65-71
作者:  Zhao, Yue;  Guo, Chuanlong;  Wang, Lijun;  Wang, Shuaiyu;  Li, Xiangqian;  Jiang, Bo;  Wu, Ning;  Guo, Shuju;  Zhang, Renshuai;  Liu, Kun;  Shi, Dayong
Adobe PDF(1849Kb)  |  收藏  |  浏览/下载：367/0  |  提交时间：2018/01/11
Thiosemicarbazone  Anticancer  2-(3  Apoptosis  4-difluorobenzylidene) Hydrazinecarbothioamide  Ros  Mitochondria-dependent Pathway  
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 134, 页码: 24-33
作者:  Zhang, Renshuai;  Yu, Rilei;  Xu, Qi;  Li, Xiangqian;  Luo, Jiao;  Jiang, Bo;  Wang, Lijun;  Guo, Shuju;  Wu, Ning;  Shi, Dayong
Adobe PDF(3126Kb)  |  收藏  |  浏览/下载：276/0  |  提交时间：2017/07/10
Ptp1b  Bromophenol  Saccharide  Selectivity  Permeability  
Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 11, 页码: 2488-2492
作者:  Zhang, Renshuai;  Song, Lairong;  Jiang, Bo;  Wang, Lijun;  Wu, Ning;  Guo, Shuju;  Shi, Dayong
Adobe PDF(1892Kb)  |  收藏  |  浏览/下载：243/0  |  提交时间：2017/09/30
Saccharide  Glut1  Drug Design  Anticancer  Cell Uptake  
A New Furanone Isolated from a Marine-Derived Actinomycete M159 期刊论文
CHEMISTRY OF NATURAL COMPOUNDS, 2015, 卷号: 51, 期号: 3, 页码: 480-482
作者:  Guo, Shuju;  Su, Hua;  Li, Xiancui;  Shi, Dayong;  Zhu, Xiaobin
Adobe PDF(133Kb)  |  收藏  |  浏览/下载：216/1  |  提交时间：2015/07/27
Marine-derived Actinomycetes  Furanone  
Chemical constituents and antioxidant activities of waste liquid extract from Apostichopus japonicus Selenka processing 期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2013, 卷号: 31, 期号: 4, 页码: 850-859
作者:  Li Chaofeng;  Li Xiancui;  Li Hong;  Guo Shuju;  Zhu Xiaobin;  Zhu, XB
Adobe PDF(465Kb)  |  收藏  |  浏览/下载：209/0  |  提交时间：2014/07/17
Waste Liquid  Extraction  Antioxidant Activity  Chemical Constituents  
Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 64, 页码: 129-136
作者:  Jiang, Bo;  Guo, Shuju;  Shi, Dayong;  Guo, Chao;  Wang, Tao;  Shi, DY
Adobe PDF(1213Kb)  |  收藏  |  浏览/下载：328/1  |  提交时间：2014/07/17
Type 2 Diabetes Mellitus  Protein Tyrosine Phosphatase 1b  Bromophenol  Anti-diabetic Activities  
HPN, a Synthetic Analogue of Bromophenol from Red Alga Rhodomela confervoides: Synthesis and Anti-Diabetic Effects in C57BL/KsJ-db/db Mice 期刊论文
MARINE DRUGS, 2013, 卷号: 11, 期号: 2, 页码: 350-362
作者:  Shi, Dayong;  Guo, Shuju;  Jiang, Bo;  Guo, Chao;  Wang, Tao;  Zhang, Luyong;  Li, Jingya;  Shi, DY
Adobe PDF(662Kb)  |  收藏  |  浏览/下载：280/0  |  提交时间：2014/07/17
Bromophenol  Protein Tyrosine Phosphatase 1b Inhibitor  Db/db Mouse Model  Anti-diabetes Properties  
Design, Synthesis, and Biological Evaluation of Bromophenol Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors 期刊论文
ARCHIV DER PHARMAZIE, 2012, 卷号: 345, 期号: 6, 页码: 444-453
作者:  Jiang, Bo;  Shi, Dayong;  Cui, Yongchao;  Guo, Shuju;  Shi, DY (reprint author), Chinese Acad Sci, R&D Ctr Marine Biotechnol, Inst Oceanol, Qingdao, Peoples R China.
Adobe PDF(473Kb)  |  收藏  |  浏览/下载：270/1  |  提交时间：2013/09/24
Bromophenol  Protein Tyrosine Phosphatase 1b Inhibitor  Structure-activity Relationship  Type 2 Diabetes Mellitus  
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 8, 页码: 2827-2832
作者:  Shi, Dayong;  Li, Jing;  Jiang, Bo;  Guo, Shuju;  Su, Hua;  Wang, Tao;  Shi, DY (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
Adobe PDF(448Kb)  |  收藏  |  浏览/下载：343/1  |  提交时间：2013/09/24
Bromophenol Derivatives  Protein Tyrosine Phosphatase 1b  Diarylmethane  Antidiabetic Activities  
Effects of alga polysaccharide capsule shells on in-vivo bioavailability and disintegration 期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2012, 卷号: 30, 期号: 1, 页码: 22-28
作者:  Li Ting;  Guo Shuju;  Ma Lin;  Yuan Yi;  Han Lijun;  Han, LJ (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
Adobe PDF(391Kb)  |  收藏  |  浏览/下载：170/0  |  提交时间：2013/09/24
Bioavailability  Bioequivalence  Gamma-scintigraphy  Vegetable Capsules  Gelatin Capsules