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金属有机框架载控缓蚀体系构建与动力学响应机制研究 学位论文
, 中国科学院海洋研究所: 中国科学院大学, 2022
作者:  孙欣
Adobe PDF(14109Kb)  |  收藏  |  浏览/下载：172/0  |  提交时间：2022/06/09
金属有机框架  缓蚀剂  负载  动力学  响应  
Design of Chitosan Sterilization Agents by a Structure Combination Strategy and Their Potential Application in Crop Protection 期刊论文
MOLECULES, 2021, 卷号: 26, 期号: 11, 页码: 15
作者:  Liu, Weixiang;  Qin, Yukun;  Li, Pengcheng
Adobe PDF(1133Kb)  |  收藏  |  浏览/下载：146/0  |  提交时间：2021/12/07
chitosan derivative  structure combination strategy  modification  agriculture  antimicrobial application  
海链藻几丁质代谢相关基因挖掘及初步功能验证 学位论文
理学硕士, 中国科学院海洋研究所: 中国科学院大学, 2021
作者:  成浩淼
Adobe PDF(3909Kb)  |  收藏  |  浏览/下载：506/0  |  提交时间：2021/06/04
硅藻  几丁质代谢  基因家族  全长转录本  功能验证  
Novel poly (ADP-ribose) polymerases inhibitor DHC-1 exhibits in vitro and in vivo anticancer activity on BRCA-deficient pancreatic cancer cells 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2021, 卷号: 147, 页码: 10
作者:  Wu, Xiaochen;  Li, Qiqi;  Zhang, Fan;  Wang, Lijun;  Wang, Jun;  Fan, Junting;  Di, Guohu;  Guo, Chuanlong
Adobe PDF(8144Kb)  |  收藏  |  浏览/下载：173/0  |  提交时间：2021/04/21
PARP inhibitor  BRCA  Pancreatic cancer  
卤代噻唑胺基类化合物的抗三阴性乳腺癌活性研究 学位论文
工学硕士学位, 中国科学院海洋研究所: 中国科学院大学, 2020
作者:  张佳佳
Adobe PDF(1995Kb)  |  收藏  |  浏览/下载：183/0  |  提交时间：2020/06/11
卤代噻唑  抗肿瘤  三阴性乳腺癌  Mda-mb-231  
BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 150, 页码: 238-245
作者:  Guo, Chuanlong;  Zhang, Fan;  Wu, Xiaochen;  Yu, Xuemin;  Wu, Xianggen;  Shi, Dayong;  Wang, Lijun
Adobe PDF(1767Kb)  |  收藏  |  浏览/下载：182/0  |  提交时间：2020/09/23
PARP-1 inhibitor  DNA double-strand breaks  HCC-1937  In vivo  Apoptosis  
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study 期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
作者:  Li, Xiuxue;  Wang, Lijun;  Jia, Xiaoling;  Guo, Chuanlong;  Li, Chao;  Zhang, Jiajia;  Shi, Dayong
Adobe PDF(579Kb)  |  收藏  |  浏览/下载：154/0  |  提交时间：2020/09/23
Novel compound  Quantitation  UHPLC-TOF-MS  Pharmacokinetics  
Superamphiphobic aluminum alloy with low sliding angles and acid-alkali liquids repellency 期刊论文
MATERIALS & DESIGN, 2020, 卷号: 188, 页码: 9
作者:  Zhang, Binbin;  Zeng, Yuxiang;  Wang, Jia;  Sun, Yuanyuan;  Zhang, Jie;  Li, Yantao
Adobe PDF(4036Kb)  |  收藏  |  浏览/下载：168/0  |  提交时间：2020/09/23
Micro-nano  Superhydrophobic  Superamphiphobic  Chemical stability  Self-cleaning  
The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21, 期号: 3, 页码: 15
作者:  Zhang, Jiajia;  Dai, Jiajia;  Zheng, Qingxuan;  Guo, Shuju;  Yu, Yanyan;  Hu, Wenpeng;  Gao, Yanan;  Shi, Dayong
Adobe PDF(2858Kb)  |  收藏  |  浏览/下载：149/0  |  提交时间：2020/09/23
triple negative breast cancer  MDA-MB-231 cells  fluoro-thiazolylhydrazone  MAPK pathway  phosphorylated p44/42 MAPK (ERK1/2)  phosphorylated c-Jun N-terminal kinase (p-JNK)  apoptosis  
Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 153-170
作者:  Wang, Lijun;  Guo, Chuanlong;  Li, Xiuxue;  Yu, Xuemin;  Li, Xiangqian;  Xu, Kuo;  Jiang, Bo;  Jia, Xiaoling;  Li, Chao;  Shi, Dayong
Adobe PDF(4835Kb)  |  收藏  |  浏览/下载：320/0  |  提交时间：2019/08/29
Bromophenol-thiazolylhydrazone hybrids  Synthesis  Multifunctional agents  eIF4E/eIF4G interaction  Autophagy  ROS