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Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo 期刊论文
CHEMISTRY & BIODIVERSITY, 2024, 页码: 11
作者:  Sun, Hao;  Bai, Xiaoyi;  Zhang, Yiting;  Gao, Yanan;  Dai, Jiajia;  Xing, Pan;  Zhu, Jiqiang;  Liu, Ruihua;  Wang, Zemin;  Li, Xiangqian
收藏  |  浏览/下载：4/0  |  提交时间：2024/06/04
Anti-tumor  SHP2  Orthosteric inhibitor  Apoptosis  Bromophenol  
JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia;  Liu, Ming
收藏  |  浏览/下载：25/0  |  提交时间：2024/04/07
Acquired resistance  Cancer  NSCLC  JC-010a  SHP2  
Comparative chromatin dynamics reveal differential thermal tolerance mechanisms between two congeneric oyster species 期刊论文
AQUACULTURE, 2024, 卷号: 579, 页码: 16
作者:  Wang, Chaogang;  Jiang, Zhuxiang;  Du, Mingyang;  Li, Qingyuan;  Cong, Rihao;  Wang, Wei;  Zhang, Guofan;  Li, Li
收藏  |  浏览/下载：22/0  |  提交时间：2024/04/07
Crassostrea gigas  Crassostrea angulata  ATAC-seq  RNA-Seq  Thermal tolerance  
Synergistic modulation of neuroendocrine-inflammation pathway by microRNAs facilitates intertidal adaptation of molluscs 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 142, 页码: 10
作者:  Chen, Hao;  Wang, Lin;  Wang, Lingling;  Zhang, Huan;  Wang, Hao;  Song, Linsheng
Adobe PDF(6028Kb)  |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07
Inflammation response  Calmodulin  Nitrite oxide  Tumor necrosis factor  miRNAs  Aerial exposure  
Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 266, 页码: 11
作者:  Ding, Kui;  Xu, Qinzeng;  Zhang, Xuelei;  Liu, Shilin
Adobe PDF(3947Kb)  |  收藏  |  浏览/下载：6/0  |  提交时间：2024/04/07
Apostichopus japonicus  BDE-47  Nervous system  UPLC-Triple-TOF-MS  Metabolite  Neurotoxicity  
Autophagy contributes to increase the content of intracellular free amino acids in hard clam (Mercenaria mercenaria) during prolonged exposure to hypersaline environments 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Zou, Yan;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Song, Hao;  Zhang, Tao
Adobe PDF(5375Kb)  |  收藏  |  浏览/下载：207/1  |  提交时间：2023/11/30
Hyposalinity  Hypersalinity  Transcriptome  Autophagy  Free amino acids  
Population genetic structure and implication for adaptive differentiation of the snail (Gastropoda, Provannidae) in deep-sea chemosynthetic ecosystems 期刊论文
ZOOLOGICA SCRIPTA, 2023, 页码: 15
作者:  Zhang, Yu;  Cheng, Jiao;  Sha, Zhongli;  Hui, Min
Adobe PDF(5970Kb)  |  收藏  |  浏览/下载：163/0  |  提交时间：2023/11/30
adaptive evolution  chemosynthetic ecosystem  gastropod  population genetics  RAD-seq  
Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 141, 页码: 11
作者:  Wang, Feifei;  Zhao, Fei;  Tan, Aiping;  Deng, Yuting;  Wang, Ling;  Gong, Hua;  Lai, Yingliao;  Huang, Zhibin;  Li, Fuhua
Adobe PDF(6146Kb)  |  收藏  |  浏览/下载：128/0  |  提交时间：2023/11/30
Macrobrachium rosenbergii  miRNA-mRNA  Immunity  Autophagy  Aeromonas hydrophila  
ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 141, 页码: 11
作者:  Zhou, Cong;  Zou, Yan;  Hu, Zhi;  Yang, Mei-jie;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(8330Kb)  |  收藏  |  浏览/下载：38/1  |  提交时间：2024/04/07
Air exposure  Resistance  Haemocytes  Oxidative stress  Autophagy  
Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench 期刊论文
VIRULENCE, 2022, 卷号: 13, 期号: 1, 页码: 1062-1075
作者:  Wang, Yujian;  Zhang, Jian;  Yuan, Zihao;  Sun, Li
Adobe PDF(22363Kb)  |  收藏  |  浏览/下载：244/0  |  提交时间：2022/07/18
Bacillus cereus  deep sea  pathogenicity  cytotoxicity  spore