Institutional Repository of Key Laboratory of Marine Ecology & Environmental Sciences, CAS
| Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus | |
Ding, Kui1,2,3 ; Xu, Qinzeng1,2; Zhang, Xuelei1,2; Liu, Shilin3
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| 2023-11-01 | |
| Source Publication | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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| ISSN | 0147-6513 |
| Volume | 266Pages:11 |
| Corresponding Author | Ding, Kui(dingkui@fio.org.cn) |
| Abstract | The persistent organic pollutant 2,2 ',4,4 '-Tetrabromodiphenyl ether (BDE-47), a prevalent congener among polybrominated diphenyl ethers (PBDEs), exhibits potent bioaccumulation and toxicity. Despite extensive research into the adverse effects of BDE-47, its neurotoxicity in sea cucumbers remains unexplored. Given the crucial role of the sea cucumber's nervous system in survival and adaptation, evaluating the impacts of BDE-47 is vital for sustainable aquaculture and consumption. In this study, we employed ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS) to analyze metabolomic changes in neuro-related tissues of Apostichopus japonicus exposed to low (0.1 mu g/L), medium (1.0 mu g/L), and high (10.0 mu g/L) BDE-47 concentrations. We identified significantly changed metabolites in each exposure group (87 in low, 79 in medium, and 102 in high), affecting a variety of physiological processes such as steroid hormone balance, nucleotide metabolism, energy metabolism, neurotransmitter levels, and neuroprotection. In addition, we identified concentration-dependent, common, and some other metabolic responses in the neuro-related tissues. Our findings reveal critical insights into the neurotoxic effects of BDE-47 in sea cucumbers and contribute to risk assessment related to BDE-47 exposure in the sea cucumber industry, paving the way for future neurotoxicological research in invertebrates. |
| Keyword | Apostichopus japonicus BDE-47 Nervous system UPLC-Triple-TOF-MS Metabolite Neurotoxicity |
| DOI | 10.1016/j.ecoenv.2023.115558 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Founda-tion of China[42106131] |
| WOS Research Area | Environmental Sciences & Ecology ; Toxicology |
| WOS Subject | Environmental Sciences ; Toxicology |
| WOS ID | WOS:001095010000001 |
| Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS Keyword | POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; OXIDATIVE STRESS ; CALCIUM HOMEOSTASIS ; NEONATAL EXPOSURE ; ACID-METABOLISM ; SERINE RACEMASE ; IMMUNE FUNCTION ; VITAMIN-A ; BEHAVIOR |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/183844 |
| Collection | 海洋生态与环境科学重点实验室 |
| Corresponding Author | Ding, Kui |
| Affiliation | 1.Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Ecoenvironm Sci & Technol, Qingdao 266061, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266061, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China |
| First Author Affilication | Key Laboratory of Marine Ecology & Environmental Sciences, CAS |
| Corresponding Author Affilication | Key Laboratory of Marine Ecology & Environmental Sciences, CAS |
| Recommended Citation GB/T 7714 | Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,et al. Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2023,266:11. |
| APA | Ding, Kui,Xu, Qinzeng,Zhang, Xuelei,&Liu, Shilin.(2023).Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,266,11. |
| MLA | Ding, Kui,et al."Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 266(2023):11. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S014765132301（3947KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | View | |
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