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Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench
Wang, Yujian1,2,3,4; Zhang, Jian5; Yuan, Zihao1,2; Sun, Li1,2,3,4
2022-12-31
发表期刊VIRULENCE
ISSN2150-5594
卷号13期号:1页码:1062-1075
通讯作者Yuan, Zihao(yuanzihao@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn)
摘要Bacillus cereus is an important opportunistic pathogen widely distributed in the environment. In this study, we reported the isolation and characterization of a B. cereus isolate, MB1, from the Challenger Deep of the Mariana Trench. MB1 is aerobic, motile, and able to form endospores. It possesses 5966 genes distributed on a circular chromosome and two plasmids. The MB1 genome contains 14 sets of 23S, 5S, and 16S ribosomal RNA operons, 106 tRNA genes, 4 sRNA genes, 12 genomic islands, 13 prophages, and 302 putative virulence genes, including enterotoxins and cytolysins. Infection studies showed that MB1 was able to cause acute and lethal infection in fish and mice, and was highly toxic to mammalian cells. MB1 induced, in a dose-dependent manner, pyroptotic cell death, characterized by activation of caspase-1, cleavage of gasdermin D, and release of IL-1 beta and IL-18. MB1 spores exhibited swimming and haemolytic capacity, but were severely attenuated in pathogenicity, which, however, was regained to the full extent when the spores germinated under suitable conditions. Taken together, these results provide new insights into the biological and pathogenic mechanism of deep sea B. cereus.
关键词Bacillus cereus deep sea pathogenicity cytotoxicity spore
DOI10.1080/21505594.2022.2088641
收录类别SCI
语种英语
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050402] ; CAS Key Laboratory of Molecular Virology Immunology[KLMVI-OP-202002] ; Taishan Scholar Program of Shandong Province ; Institut Pasteur of Shanghai, Chinese Academy of Sciences
WOS研究方向Immunology ; Infectious Diseases ; Microbiology
WOS类目Immunology ; Infectious Diseases ; Microbiology
WOS记录号WOS:000814954900001
出版者TAYLOR & FRANCIS INC
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/179143
专题实验海洋生物学重点实验室
通讯作者Yuan, Zihao; Sun, Li
作者单位1.Chinese Acad Sci, Qingdao, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China
5.Yan Tai Univ, Sch Ocean, Yantai, Peoples R China
第一作者单位中国科学院海洋大科学研究中心
通讯作者单位中国科学院海洋大科学研究中心
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Wang, Yujian,Zhang, Jian,Yuan, Zihao,et al. Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench[J]. VIRULENCE,2022,13(1):1062-1075.
APA Wang, Yujian,Zhang, Jian,Yuan, Zihao,&Sun, Li.(2022).Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench.VIRULENCE,13(1),1062-1075.
MLA Wang, Yujian,et al."Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench".VIRULENCE 13.1(2022):1062-1075.
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