Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila

doi:10.1016/j.fsi.2023.109052

IOCAS-IR > 实验海洋生物学重点实验室

	Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila
	Wang, Feifei 1,2,3; Zhao, Fei 1,5; Tan, Aiping 1; Deng, Yuting 1; Wang, Ling4 ; Gong, Hua 1; Lai, Yingliao 1; Huang, Zhibin 1; Li, Fuhua 2,3
	2023-10-01
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
卷号	141 页码:11
通讯作者	Zhao, Fei(zhaofei@prfri.ac.cn)
摘要	MicroRNAs (miRNAs) are a group of RNAs that regulate gene expression in the post-transcriptionally. miRNAs can regulate numerous processes, such as the immune response, due to their dynamic expression patterns. The giant freshwater prawn Macrobrachium rosenbergii is a major freshwater aquaculture prawn that is attacked by various bacteria, including Aeromonas hydrophila. For this study, we performed an analysis of the miRNA and mRNA transcriptome analysis of M. rosenbergii which was infected with A. hydrophila. We identified 56 differentially expressed miRNAs (DEMs) and 1542 differentially expressed mRNAs. Furthermore, an integrated analysis of miRNA-mRNA expression led to the identification of 729 differentially predicted target genes (DETGs) of the DEMs. Multiple functional categories related to immunity, apoptosis, and autophagy were found to be enriched in the DETGs. During the infection of M. rosenbergii by A. hydrophila, an elaborate regulatory network involving Toll and immune deficiency (IMD) signaling, mitogen-activated protein kinase (MAPK) signaling, lysosome, and cell apoptosis was formed by a complex interplay of 40 crucial DEMs and 22 DETGs, all associated with the immune and autophagy pathway. The findings suggest that infection with A. hydrophila triggers intricate responses in both miRNA and mRNA, significantly impacting immune and autophagy processes in M. rosenbergii.
关键词	Macrobrachium rosenbergii miRNA-mRNA Immunity Autophagy Aeromonas hydrophila
DOI	10.1016/j.fsi.2023.109052
收录类别	SCI
语种	英语
资助项目	Independent project of Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology[P20211154-0102-01] ; Science and Technology Plan Project of Guangzhou[2023B03J1305] ; Central Public-interest Scientific Institution Basal Research Fund, CAFS[2022GH04] ; Central Public-interest Scientific Institution Basal Research Fund, CAFS[2021SJ-XT3] ; Central Public-interest Scientific Institution Basal Research Fund, CAFS[2020TD45] ; Government Procurement Project of Agriculture and Rural Bureau of Nanhai District in Foshan[2967855]
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:001091474500001
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS关键词	NF-KAPPA-B ; DIFFERENTIAL EXPRESSION ; GENE ; MICRORNAS ; APOPTOSIS ; PATHWAYS ; PROTEINS ; VANNAMEI ; CASPASE ; SHRIMP
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181590
专题	实验海洋生物学重点实验室
通讯作者	Zhao, Fei
作者单位	1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev, Guangdong Prov Key Lab Aquat Anim Immunol & Sustai, Guangzhou 510380, Peoples R China 2.Chinese Acad Sci, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Guangdong Lab Lingnan Modern Agr Sci & Technol, Zhaoqing Branch Ctr, Zhaoqing 526238, Peoples R China 5.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, 1 Xingyu Rd, Guangzhou 510380, Guangdong, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wang, Feifei,Zhao, Fei,Tan, Aiping,et al. Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila[J]. FISH & SHELLFISH IMMUNOLOGY,2023,141:11.
APA	Wang, Feifei.,Zhao, Fei.,Tan, Aiping.,Deng, Yuting.,Wang, Ling.,...&Li, Fuhua.(2023).Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila.FISH & SHELLFISH IMMUNOLOGY,141,11.
MLA	Wang, Feifei,et al."Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila".FISH & SHELLFISH IMMUNOLOGY 141(2023):11.

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