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Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila
Wang, Feifei1,2,3; Zhao, Fei1,5; Tan, Aiping1; Deng, Yuting1; Wang, Ling4; Gong, Hua1; Lai, Yingliao1; Huang, Zhibin1; Li, Fuhua2,3
2023-10-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume141Pages:11
Corresponding AuthorZhao, Fei(zhaofei@prfri.ac.cn)
AbstractMicroRNAs (miRNAs) are a group of RNAs that regulate gene expression in the post-transcriptionally. miRNAs can regulate numerous processes, such as the immune response, due to their dynamic expression patterns. The giant freshwater prawn Macrobrachium rosenbergii is a major freshwater aquaculture prawn that is attacked by various bacteria, including Aeromonas hydrophila. For this study, we performed an analysis of the miRNA and mRNA transcriptome analysis of M. rosenbergii which was infected with A. hydrophila. We identified 56 differentially expressed miRNAs (DEMs) and 1542 differentially expressed mRNAs. Furthermore, an integrated analysis of miRNA-mRNA expression led to the identification of 729 differentially predicted target genes (DETGs) of the DEMs. Multiple functional categories related to immunity, apoptosis, and autophagy were found to be enriched in the DETGs. During the infection of M. rosenbergii by A. hydrophila, an elaborate regulatory network involving Toll and immune deficiency (IMD) signaling, mitogen-activated protein kinase (MAPK) signaling, lysosome, and cell apoptosis was formed by a complex interplay of 40 crucial DEMs and 22 DETGs, all associated with the immune and autophagy pathway. The findings suggest that infection with A. hydrophila triggers intricate responses in both miRNA and mRNA, significantly impacting immune and autophagy processes in M. rosenbergii.
KeywordMacrobrachium rosenbergii miRNA-mRNA Immunity Autophagy Aeromonas hydrophila
DOI10.1016/j.fsi.2023.109052
Indexed BySCI
Language英语
Funding ProjectIndependent project of Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology[P20211154-0102-01] ; Science and Technology Plan Project of Guangzhou[2023B03J1305] ; Central Public-interest Scientific Institution Basal Research Fund, CAFS[2022GH04] ; Central Public-interest Scientific Institution Basal Research Fund, CAFS[2021SJ-XT3] ; Central Public-interest Scientific Institution Basal Research Fund, CAFS[2020TD45] ; Government Procurement Project of Agriculture and Rural Bureau of Nanhai District in Foshan[2967855]
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:001091474500001
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS KeywordNF-KAPPA-B ; DIFFERENTIAL EXPRESSION ; GENE ; MICRORNAS ; APOPTOSIS ; PATHWAYS ; PROTEINS ; VANNAMEI ; CASPASE ; SHRIMP
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/181590
Collection实验海洋生物学重点实验室
Corresponding AuthorZhao, Fei
Affiliation1.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Fishery Drug Dev, Guangdong Prov Key Lab Aquat Anim Immunol & Sustai, Guangzhou 510380, Peoples R China
2.Chinese Acad Sci, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
4.Guangdong Lab Lingnan Modern Agr Sci & Technol, Zhaoqing Branch Ctr, Zhaoqing 526238, Peoples R China
5.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, 1 Xingyu Rd, Guangzhou 510380, Guangdong, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Feifei,Zhao, Fei,Tan, Aiping,et al. Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila[J]. FISH & SHELLFISH IMMUNOLOGY,2023,141:11.
APA Wang, Feifei.,Zhao, Fei.,Tan, Aiping.,Deng, Yuting.,Wang, Ling.,...&Li, Fuhua.(2023).Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila.FISH & SHELLFISH IMMUNOLOGY,141,11.
MLA Wang, Feifei,et al."Integrated analysis of a miRNA-mRNA network related to immunity and autophagy in Macrobrachium rosenbergii infected with Aeromonas hydrophila".FISH & SHELLFISH IMMUNOLOGY 141(2023):11.
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