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Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Guo, Shu-Ju;  Li, Xiang-Qian;  Chen, Xue-Chun;  Luo, Jiao;  Li, Chao;  Wang, Yi;  Shi, Da-Yong
Adobe PDF(824Kb)  |  收藏  |  浏览/下载：302/0  |  提交时间：2019/08/21
Pyrimidinedionederivatives  DPP-4 inhibitor  Molecular hybrid  SARs  Type 2 diabetes  
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 145-157
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Li, Xiang-qian;  Guo, Chuan-long;  Guo, Shu-ju;  Shi, Da-Yong
Adobe PDF(1523Kb)  |  收藏  |  浏览/下载：299/0  |  提交时间：2019/08/21
DPP-4  Inhibitors  Analogs  Physico-chemical properties  SARs  Type 2 diabetes  
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway 期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 2, 页码: 13
作者:  Guo, Chuan-Long;  Wang, Li-Jun;  Zhao, Yue;  Liu, Hua;  Li, Xiang-Qian;  Jiang, Bo;  Luo, Jiao;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
Adobe PDF(5208Kb)  |  收藏  |  浏览/下载：340/0  |  提交时间：2019/08/21
bromophenol  molecular mechanisms  apoptosis  cell cycle  PI3K  Akt  p38  ERK  ROS  human lung cancer  
Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation 期刊论文
MARINE DRUGS, 2017, 卷号: 15, 期号: 11, 页码: 18
作者:  Wang, Li-Jun;  Guo, Chuan-Long;  Li, Xiang-Qian;  Wang, Shuai-Yu;  Jiang, Bo;  Zhao, Yue;  Luo, Jiao;  Xu, Kuo;  Liu, Hua;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
收藏  |  浏览/下载：313/0  |  提交时间：2019/07/15
bromophenol hybrids  anticancer  structure-activity relationships  ROS  apoptotic pathway  
The oyster genome reveals stress adaptation and complexity of shell formation 期刊论文
NATURE, 2012, 卷号: 490, 期号: 7418, 页码: 49-54
作者:  Zhang, Guofan;  Fang, Xiaodong;  Guo, Ximing;  Li, Li;  Luo, Ruibang;  Xu, Fei;  Yang, Pengcheng;  Zhang, Linlin;  Wang, Xiaotong;  Qi, Haigang;  Xiong, Zhiqiang;  Que, Huayong;  Xie, Yinlong;  Holland, Peter W. H.;  Paps, Jordi;  Zhu, Yabing;  Wu, Fucun;  Chen, Yuanxin;  Wang, Jiafeng;  Peng, Chunfang;  Meng, Jie;  Yang, Lan;  Liu, Jun;  Wen, Bo;  Zhang, Na;  Huang, Zhiyong;  Zhu, Qihui;  Feng, Yue;  Mount, Andrew;  Hedgecock, Dennis;  Xu, Zhe;  Liu, Yunjie;  Domazet-Loso, Tomislav;  Du, Yishuai;  Sun, Xiaoqing;  Zhang, Shoudu;  Liu, Binghang;  Cheng, Peizhou;  Jiang, Xuanting;  Li, Juan;  Fan, Dingding;  Wang, Wei;  Fu, Wenjing;  Wang, Tong;  Wang, Bo;  Zhang, Jibiao;  Peng, Zhiyu;  Li, Yingxiang;  Li, Na;  Wang, Jinpeng;  Chen, Maoshan;  He, Yan;  Tan, Fengji;  Song, Xiaorui;  Zheng, Qiumei;  Huang, Ronglian;  Yang, Hailong;  Du, Xuedi;  Chen, Li;  Yang, Mei;  Gaffney, Patrick M.;  Wang, Shan;  Luo, Longhai;  She, Zhicai;  Ming, Yao;  Huang, Wen;  Zhang, Shu;  Huang, Baoyu;  Zhang, Yong;  Qu, Tao;  Ni, Peixiang;  Miao, Guoying;  Wang, Junyi;  Wang, Qiang;  Steinberg, Christian E. W.;  Wang, Haiyan;  Li, Ning;  Qian, Lumin;  Zhang, Guojie;  Li, Yingrui;  Yang, Huanming;  Liu, Xiao;  Wang, Jian;  Yin, Ye;  Wang, Jun;  Wang, J (reprint author), BGI Shenzhen, Shenzhen 518083, Peoples R China.
Adobe PDF(712Kb)  |  收藏  |  浏览/下载：1384/2  |  提交时间：2013/09/24
Transposable Elements  Crassostrea-gigas  Bivalve Mollusks  Parahox Genes  Proteins  Sequence  Evolution  Discovery  Apoptosis  Pathway  
Two new bromoindoles from red alga Laurencia similis 期刊论文
CHINESE CHEMICAL LETTERS, 2009, 卷号: 20, 期号: 4, 页码: 456-458
作者:  Su, Hua;  Yuan, Zhao Hui;  Li, Jing;  Guo, Shu Ju;  Deng, Li Ping;  Han, Li Jun;  Bin Zhu, Xiao;  Shi, Da Yong
Adobe PDF(145Kb)  |  收藏  |  浏览/下载：289/0  |  提交时间：2010/12/22
Laurencia Similis  Bromoindole Alkaloid  2  2 '  3  5  5-dibromo-1-methylindole  5 '  6  6 '-sixibromo-3  3 '-bi-1h-indole  
Sesquiterpenes from the Marine Red Alga Laurencia saitoi 期刊论文
HELVETICA CHIMICA ACTA, 2009, 卷号: 92, 期号: 7, 页码: 1291-1297
作者:  Su, Hua;  Yuan, Zhao-Hui;  Li, Jing;  Guo, Shu-Ju;  Deng, Li-Ping;  Han, Li-Jun;  Zhu, Xiao-Bin;  Shi, Da-Yong
Adobe PDF(175Kb)  |  收藏  |  浏览/下载：305/2  |  提交时间：2010/12/22
Derivatives  
Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor 期刊论文
CHINESE CHEMICAL LETTERS, 2008, 卷号: 19, 期号: 11, 页码: 1290-1292
作者:  Li, Jing;  Guo, Shu Ju;  Su, Hua;  Han, Li Jun;  shi, Da Yong
Adobe PDF(181Kb)  |  收藏  |  浏览/下载：308/0  |  提交时间：2010/12/24
Bromophenol  Ptp1b Inhibitor  Bis-(2  Total Synthesis  3-dibromo-4  5-dihydroxyphenyl)-methane