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The oyster genome reveals stress adaptation and complexity of shell formation
Zhang, Guofan2; Fang, Xiaodong1; Guo, Ximing3; Li, Li2; Luo, Ruibang1,4; Xu, Fei2; Yang, Pengcheng1; Zhang, Linlin2; Wang, Xiaotong2; Qi, Haigang2; Xiong, Zhiqiang1; Que, Huayong2; Xie, Yinlong1,4; Holland, Peter W. H.5; Paps, Jordi5; Zhu, Yabing1; Wu, Fucun2; Chen, Yuanxin1; Wang, Jiafeng2; Peng, Chunfang1; Meng, Jie2; Yang, Lan1; Liu, Jun2; Wen, Bo1; Zhang, Na2; Huang, Zhiyong1; Zhu, Qihui2; Feng, Yue1; Mount, Andrew6; Hedgecock, Dennis7; Xu, Zhe8; Liu, Yunjie1; Domazet-Loso, Tomislav9; Du, Yishuai2; Sun, Xiaoqing1; Zhang, Shoudu2; Liu, Binghang1,4; Cheng, Peizhou2; Jiang, Xuanting1; Li, Juan2; Fan, Dingding1; Wang, Wei2; Fu, Wenjing1; Wang, Tong2; Wang, Bo1; Zhang, Jibiao2; Peng, Zhiyu1; Li, Yingxiang2; Li, Na1; Wang, Jinpeng2; Chen, Maoshan1; He, Yan3; Tan, Fengji1; Song, Xiaorui2; Zheng, Qiumei1; Huang, Ronglian2; Yang, Hailong1; Du, Xuedi2; Chen, Li1; Yang, Mei2; Gaffney, Patrick M.10; Wang, Shan3; Luo, Longhai1; She, Zhicai2; Ming, Yao1; Huang, Wen2; Zhang, Shu1; Huang, Baoyu2; Zhang, Yong1; Qu, Tao2; Ni, Peixiang1; Miao, Guoying2; Wang, Junyi1; Wang, Qiang2; Steinberg, Christian E. W.11; Wang, Haiyan2; Li, Ning1; Qian, Lumin3; Zhang, Guojie1; Li, Yingrui1; Yang, Huanming1; Liu, Xiao2; Wang, Jian1; Yin, Ye1; Wang, Jun1,12,13; Wang, J (reprint author), BGI Shenzhen, Shenzhen 518083, Peoples R China.
Source PublicationNATURE
AbstractThe Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is highly polymorphic and rich in repetitive sequences, with some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set of genes responding to environmental stress. The expansion of genes coding for heat shock protein 70 and inhibitors of apoptosis is probably central to the oyster's adaptation to sessile life in the highly stressful intertidal zone. Our analyses also show that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. The oyster genome sequence fills a void in our understanding of the Lophotrochozoa.
KeywordTransposable Elements Crassostrea-gigas Bivalve Mollusks Parahox Genes Proteins Sequence Evolution Discovery Apoptosis Pathway
Subject AreaMultidisciplinary Sciences
Indexed BySCI
WOS IDWOS:000309446800030
Citation statistics
Cited Times:1670[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang, J (reprint author), BGI Shenzhen, Shenzhen 518083, Peoples R China.
Affiliation1.BGI Shenzhen, Shenzhen 518083, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Rutgers State Univ, Inst Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ 08349 USA
4.HKU BGI Bioinformat Algorithms & Core Technol Res, Hong Kong, Hong Kong, Peoples R China
5.Univ Oxford, Dept Zool, Oxford OX1 3PS, England
6.Clemson Univ, Dept Biol Sci, Clemson, SC 29634 USA
7.Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA
8.Atlantic Cape Community Coll, Mays Landing, NJ 08330 USA
9.Rudjer Boskovic Inst, Lab Evolutionary Genet, HR-10002 Zagreb, Croatia
10.Univ Delaware, Sch Marine Sci & Policy, Lewes, DE 19958 USA
11.Humboldt Univ Berlin Arboretum, Inst Biol, D-12437 Berlin, Germany
12.Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark
13.Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Guofan,Fang, Xiaodong,Guo, Ximing,et al. The oyster genome reveals stress adaptation and complexity of shell formation[J]. NATURE,2012,490(7418):49-54.
APA Zhang, Guofan.,Fang, Xiaodong.,Guo, Ximing.,Li, Li.,Luo, Ruibang.,...&Wang, J .(2012).The oyster genome reveals stress adaptation and complexity of shell formation.NATURE,490(7418),49-54.
MLA Zhang, Guofan,et al."The oyster genome reveals stress adaptation and complexity of shell formation".NATURE 490.7418(2012):49-54.
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