Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor

doi:10.1016/j.cclet.2008.07.002

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	Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor
	Li, Jing1,2 ; Guo, Shu Ju 1,2; Su, Hua 1,2; Han, Li Jun 1; shi, Da Yong 1
	2008-11-01
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	19 期号:11 页码:1290-1292
文章类型	Article
摘要	Protein tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator and has been proved to be an effective target for the treatment of type 2 diabetes mellitus. Bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane 7 was first reported as a natural bromophenol with significant inhibition against PTP1B which was isolated from red algae Rhodomela confervoides. Intrigued by its astonishing activity (IC(50) = 2.4 mu mol/L), compound 7 was synthesized with the overall yield of 24% and evaluated for its PTP1B inhibitory activity compared with natural compound. (C) 2008 Li Jun Han. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.; Protein tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator and has been proved to be an effective target for the treatment of type 2 diabetes mellitus. Bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane 7 was first reported as a natural bromophenol with significant inhibition against PTP1B which was isolated from red algae Rhodomela confervoides. Intrigued by its astonishing activity (IC50 = 2.4 mu mol/L), compound 7 was synthesized with the overall yield of 24% and evaluated for its PTP1B inhibitory activity compared with natural compound. (C) 2008 Li Jun Han. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
关键词	Bromophenol Ptp1b Inhibitor Bis-(2 Total Synthesis 3-dibromo-4 5-dihydroxyphenyl)-methane
学科领域	Chemistry, Multidisciplinary
DOI	10.1016/j.cclet.2008.07.002
URL	查看原文
收录类别	SCI ; CCR
语种	英语
WOS记录号	WOS:000263323500008
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/6062
专题	海洋生物技术研发中心实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Jing,Guo, Shu Ju,Su, Hua,et al. Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor[J]. CHINESE CHEMICAL LETTERS,2008,19(11):1290-1292.
APA	Li, Jing,Guo, Shu Ju,Su, Hua,Han, Li Jun,&shi, Da Yong.(2008).Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor.CHINESE CHEMICAL LETTERS,19(11),1290-1292.
MLA	Li, Jing,et al."Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor".CHINESE CHEMICAL LETTERS 19.11(2008):1290-1292.

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