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Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed 期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2020, 页码: 9
作者:  Liu Changshui;  Zang Kun;  Li Shihao;  Li Fuhua;  Ma Qingiun
Adobe PDF(1545Kb)  |  收藏  |  浏览/下载：135/0  |  提交时间：2020/09/22
thymidylate synthase (TS)  closed conformation  deoxyuridine monophosphate (dUMP)  thymidine monophosphate (TMP)  raltitrexed  Litopenaeus vannamei  
H1, a derivative of tetrandrine, enhances the efficacy of 5-FU in Bel7402/5-FU cells via suppressing STAT3/MCL-1 and inducing PUMA 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 520, 期号: 1, 页码: 93-98
作者:  Li, Fengli;  Wang, Jing;  Wu, Ning;  Zhang, Hua;  Li, Zheng;  Wei, Ning
Adobe PDF(1665Kb)  |  收藏  |  浏览/下载：208/0  |  提交时间：2020/03/20
5-FU  Drug resistance  STAT3  Hepatocellular carcinoma  MCL-1  PUMA  
Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 8, 页码: 683-692
作者:  Wang, Bao-Cheng;  Wang, Li-Jun;  Jiang, Bo;  Wang, Shuai-Yu;  Wu, Ning;  Li, Xiang-Qian;  Shi, Da-Yong
Adobe PDF(1080Kb)  |  收藏  |  浏览/下载：273/0  |  提交时间：2017/09/30
Application Of Fluorine  Anticancer  Antimicrobial  Anti-inflammatory  Antivirus Activity  Drug Design  Importance Of Fluorinated Compounds  
Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction 期刊论文
BIOMED RESEARCH INTERNATIONAL, 2014, 页码: 416543
作者:  Sun, Zheng;  Li, Shihao;  Li, Fuhua;  Xiang, Jianhai;  Li, FH (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
Adobe PDF(884Kb)  |  收藏  |  浏览/下载：240/0  |  提交时间：2015/06/11
Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells 期刊论文
JOURNAL OF APPLIED TOXICOLOGY, 2013, 卷号: 33, 期号: 8, 页码: 756-765
作者:  Wei, Jianteng;  Liu, Ming;  Liu, Haizhou;  Wang, Hui;  Wang, Fengxia;  Zhang, Yuyan;  Han, Lijun;  Lin, Xiukun;  Lin, XK
Adobe PDF(2882Kb)  |  收藏  |  浏览/下载：279/0  |  提交时间：2014/07/17
Oleanolic Acid  Apoptosis  Ros  Mitochondrial Depolarization  Lysosomal Membrane Permeabilization  
Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment 期刊论文
FEBS LETTERS, 2012, 卷号: 586, 期号: 8, 页码: 1220-1225
作者:  Zhao, Xiangzhong;  Wu, Ning;  Ding, Lili;  Liu, Ming;  Liu, Haizhou;  Lin, Xiukun;  Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
Adobe PDF(602Kb)  |  收藏  |  浏览/下载：318/0  |  提交时间：2013/09/24
P53  Zebrafish  Rna Binding Protein  Translational Regulation  
Interaction between Thymidylate Synthase and Its Cognate mRNA in Zebrafish Embryos 期刊论文
PLOS ONE, 2010, 卷号: 5, 期号: 5, 页码: e10618
作者:  Zhang, Yuyan;  Yang, Shaoli;  Liu, Ming;  Song, Chunxia;  Wu, Ning;  Ling, Peixue;  Chu, Edward;  Lin, Xiukun;  Zhang, YY, Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
Adobe PDF(545Kb)  |  收藏  |  浏览/下载：200/1  |  提交时间：2010/11/18
Binding  Protein  Autoregulation  Degradation  Expression  Induction  Mechanism  Residues  Cancer  Cells  
Interaction between Thymidylate Synthase and Its Cognate mRNA in Zebrafish Embryos 期刊论文
PLOS ONE, 2010, 卷号: 5, 期号: 5, 页码: e10618
作者:  Zhang, Yuyan;  Yang, Shaoli;  Liu, Ming;  Song, Chunxia;  Wu, Ning;  Ling, Peixue;  Chu, Edward;  Lin, Xiukun;  Zhang, YY, Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
Adobe PDF(545Kb)  |  收藏  |  浏览/下载：193/0  |  提交时间：2010/11/18
Binding  Protein  Autoregulation  Degradation  Expression  Induction  Mechanism  Residues  Cancer  Cells  
VEGF gene silencing by cytomegalovirus promoter driven ShRNA expression vector results in vascular development defects in zebrafish 期刊论文
RUSSIAN JOURNAL OF GENETICS, 2009, 卷号: 45, 期号: 9, 页码: 1040-1046
作者:  Yang, S. L.;  Yan, S.;  Niu, R. L.;  Lin, X. K.
Adobe PDF(288Kb)  |  收藏  |  浏览/下载：162/0  |  提交时间：2010/12/22
Endothelial Growth-factor  Pol-ii Promoter  Rna Interference  Angiogenesis  Hematopoiesis  Neuropilin-1  Mammals  System  Cell  
Zebrafish thymidylate synthase binds to its own mRNA in vitro and in vivo 期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2007, 卷号: 34, 期号: 12, 页码: 1321-1326
作者:  Song Chun-Xia;  Niu Rong-Li;  Du Chang-Qine;  Yang Shao-Li;  Lin Xiu-Kun
Adobe PDF(307Kb)  |  收藏  |  浏览/下载：191/1  |  提交时间：2010/12/30
Zebrafish  Thymidylate Synthase  Electrophoretic Mobility Shift Assay (Emsa)  Protein-rna Interaction  Immunoprecipitation : Rt-pcr