Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction

doi:10.1155/2014/416543

IOCAS-IR > 实验海洋生物学重点实验室

	Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction
	Sun, Zheng 1; Li, Shihao 1,2; Li, Fuhua 1,2; Xiang, Jianhai1 ; Li, FH (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
	2014
发表期刊	BIOMED RESEARCH INTERNATIONAL
页码	416543
文章类型	Article
摘要	WSSV is one of the most dangerous pathogens in shrimp aquaculture. However, the molecular mechanism of how WSSV interacts with shrimp is still not very clear. In the present study, bioinformatic approaches were used to predict interactions between proteins from WSSV and shrimp. The genome data of WSSV (NC_003225.1) and the constructed transcriptome data of F. chinensis were used to screen potentially interacting proteins by searching in protein interaction databases, including STRING, Reactome, and DIP. Forty-four pairs of proteins were suggested to have interactions between WSSV and the shrimp. Gene ontology analysis revealed that 6 pairs of these interacting proteins were classified into "extracellular region" or "receptor complex" GO-terms. KEGG pathway analysis showed that they were involved in the "ECM-receptor interaction pathway." In the 6 pairs of interacting proteins, an envelope protein called "collagen-like protein" (WSSV-CLP) encoded by an early virus gene "wsv001" in WSSV interacted with 6 deduced proteins from the shrimp, including three integrin alpha (ITGA), two integrin beta (ITGB), and one syndecan (SDC). Sequence analysis on WSSV-CLP, ITGA, ITGB, and SDC revealed that they possessed the sequence features for protein-protein interactions. This study might provide new insights into the interaction mechanisms between WSSV and shrimp.
学科领域	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
DOI	10.1155/2014/416543
收录类别	SCI
语种	英语
WOS记录号	WOS:000336597100001
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24077
专题	实验海洋生物学重点实验室
通讯作者	Li, FH (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Sun, Zheng,Li, Shihao,Li, Fuhua,et al. Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction[J]. BIOMED RESEARCH INTERNATIONAL,2014:416543.
APA	Sun, Zheng,Li, Shihao,Li, Fuhua,Xiang, Jianhai,&Li, FH .(2014).Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction.BIOMED RESEARCH INTERNATIONAL,416543.
MLA	Sun, Zheng,et al."Bioinformatic Prediction of WSSV-Host Protein-Protein Interaction".BIOMED RESEARCH INTERNATIONAL (2014):416543.

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