Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment

doi:10.1016/j.febslet.2012.03.025

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	Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment
	Zhao, Xiangzhong 1,2; Wu, Ning 1; Ding, Lili 1; Liu, Ming 1; Liu, Haizhou 1; Lin, Xiukun 1,3; Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
	2012-04-24
发表期刊	FEBS LETTERS
ISSN	0014-5793
卷号	586 期号:8 页码:1220-1225
文章类型	Article
摘要	p53 protein is an important regulatory factor involved in cell growth and development. In our previous study, we demonstrated that recombined zebrafish p53 protein could specifically bind to its own mRNA in vitro. To determine if a similar interaction exists in zebrafish and if this interaction affects zebrafish development, in the present study, we investigated the interaction of p53 protein and its mRNA in zebrafish embryos. Our results revealed that expressed zebrafish p53 protein could bind with its own mRNA in zebrafish embryos. Furthermore, the endogenous activated or ectopically expressed p53 protein could enhance the relative activity of Renilla luciferase fused with p53 3'UTR in response to UV irradiation and CPT treatment, and retarded development of zebrafish embryos was observed. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
关键词	P53 Zebrafish Rna Binding Protein Translational Regulation
学科领域	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
DOI	10.1016/j.febslet.2012.03.025
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000303106100021
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/12407
专题	实验海洋生物学重点实验室
通讯作者	Lin, XK (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Shandong Acad Med Sci, Inst Basic Med, Key Lab Rare Dis Shandong Prov, Jinan 250062, Peoples R China 3.Beijing Capital Med Univ, Dept Pharmacol, Beijing 100069, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhao, Xiangzhong,Wu, Ning,Ding, Lili,et al. Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment[J]. FEBS LETTERS,2012,586(8):1220-1225.
APA	Zhao, Xiangzhong.,Wu, Ning.,Ding, Lili.,Liu, Ming.,Liu, Haizhou.,...&Lin, XK .(2012).Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment.FEBS LETTERS,586(8),1220-1225.
MLA	Zhao, Xiangzhong,et al."Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment".FEBS LETTERS 586.8(2012):1220-1225.

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