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Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity
Zhang, Renshuai1,2; Song, Lairong4; Jiang, Bo1,2; Wang, Lijun1,2; Wu, Ning1,2; Guo, Shuju1,2; Shi, Dayong1,2,3
2017-06-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号27期号:11页码:2488-2492
文章类型Article
摘要A series of novel carbohydrate-modified antitumor compounds were designed based on glucose transporter 1 (GLUT1), and evaluated for their anticancer activities against four cancer cell lines. The ribose derivatives (compound 9 and 10) exhibited modest inhibitory activity. The compound 9 significantly inhibited the migration of A549 cell and induced A549 cell apoptosis in a concentration-dependent manner. Moreover, compound 9 blocked A549 cells at the G0/G1 phase. The cellular uptake studies suggested that ribose-modified compound 9 could be taken through GLUT1 in A549 cell line. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Saccharide Glut1 Drug Design Anticancer Cell Uptake
DOI10.1016/j.bmc1.2017.03.094
收录类别SCI
语种英语
WOS记录号WOS:000402023800043
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.qdio.ac.cn/handle/337002/137111
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Qingdao Univ, Affiliated Hosp, Dept Neurosurg, Qingdao, Peoples R China
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GB/T 7714
Zhang, Renshuai,Song, Lairong,Jiang, Bo,et al. Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(11):2488-2492.
APA Zhang, Renshuai.,Song, Lairong.,Jiang, Bo.,Wang, Lijun.,Wu, Ning.,...&Shi, Dayong.(2017).Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(11),2488-2492.
MLA Zhang, Renshuai,et al."Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.11(2017):2488-2492.
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