| Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity | |
| Zhang, Renshuai1,2; Song, Lairong4; Jiang, Bo1,2; Wang, Lijun1,2; Wu, Ning1,2; Guo, Shuju1,2; Shi, Dayong1,2,3 | |
| 2017-06-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 卷号 | 27期号:11页码:2488-2492 |
| 文章类型 | Article |
| 摘要 | A series of novel carbohydrate-modified antitumor compounds were designed based on glucose transporter 1 (GLUT1), and evaluated for their anticancer activities against four cancer cell lines. The ribose derivatives (compound 9 and 10) exhibited modest inhibitory activity. The compound 9 significantly inhibited the migration of A549 cell and induced A549 cell apoptosis in a concentration-dependent manner. Moreover, compound 9 blocked A549 cells at the G0/G1 phase. The cellular uptake studies suggested that ribose-modified compound 9 could be taken through GLUT1 in A549 cell line. (C) 2017 Elsevier Ltd. All rights reserved. |
| 关键词 | Saccharide Glut1 Drug Design Anticancer Cell Uptake |
| DOI | 10.1016/j.bmc1.2017.03.094 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402023800043 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/137111 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Qingdao Univ, Affiliated Hosp, Dept Neurosurg, Qingdao, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Renshuai,Song, Lairong,Jiang, Bo,et al. Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(11):2488-2492. |
| APA | Zhang, Renshuai.,Song, Lairong.,Jiang, Bo.,Wang, Lijun.,Wu, Ning.,...&Shi, Dayong.(2017).Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(11),2488-2492. |
| MLA | Zhang, Renshuai,et al."Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.11(2017):2488-2492. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Design of antitumor （1892KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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