IOCAS-IR  > 海洋生物技术研发中心
Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity
Zhang, Renshuai1,2; Song, Lairong4; Jiang, Bo1,2; Wang, Lijun1,2; Wu, Ning1,2; Guo, Shuju1,2; Shi, Dayong1,2,3
2017-06-01
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume27Issue:11Pages:2488-2492
SubtypeArticle
AbstractA series of novel carbohydrate-modified antitumor compounds were designed based on glucose transporter 1 (GLUT1), and evaluated for their anticancer activities against four cancer cell lines. The ribose derivatives (compound 9 and 10) exhibited modest inhibitory activity. The compound 9 significantly inhibited the migration of A549 cell and induced A549 cell apoptosis in a concentration-dependent manner. Moreover, compound 9 blocked A549 cells at the G0/G1 phase. The cellular uptake studies suggested that ribose-modified compound 9 could be taken through GLUT1 in A549 cell line. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordSaccharide Glut1 Drug Design Anticancer Cell Uptake
DOI10.1016/j.bmc1.2017.03.094
Indexed BySCI
Language英语
WOS IDWOS:000402023800043
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.qdio.ac.cn/handle/337002/137111
Collection海洋生物技术研发中心
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Qingdao Univ, Affiliated Hosp, Dept Neurosurg, Qingdao, Peoples R China
First Author Affilication中国科学院海洋研究所
Recommended Citation
GB/T 7714
Zhang, Renshuai,Song, Lairong,Jiang, Bo,et al. Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(11):2488-2492.
APA Zhang, Renshuai.,Song, Lairong.,Jiang, Bo.,Wang, Lijun.,Wu, Ning.,...&Shi, Dayong.(2017).Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(11),2488-2492.
MLA Zhang, Renshuai,et al."Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.11(2017):2488-2492.
Files in This Item:
File Name/Size DocType Version Access License
Design of antitumor (1892KB)期刊论文出版稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Renshuai]'s Articles
[Song, Lairong]'s Articles
[Jiang, Bo]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Renshuai]'s Articles
[Song, Lairong]'s Articles
[Jiang, Bo]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Renshuai]'s Articles
[Song, Lairong]'s Articles
[Jiang, Bo]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Design of antitumor agents containing carbohydrate based on GLUT1, and evaluation of antiproliferative activity.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.