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Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo 期刊论文
CHEMISTRY & BIODIVERSITY, 2024, 页码: 11
作者:  Sun, Hao;  Bai, Xiaoyi;  Zhang, Yiting;  Gao, Yanan;  Dai, Jiajia;  Xing, Pan;  Zhu, Jiqiang;  Liu, Ruihua;  Wang, Zemin;  Li, Xiangqian
收藏  |  浏览/下载：3/0  |  提交时间：2024/06/04
Anti-tumor  SHP2  Orthosteric inhibitor  Apoptosis  Bromophenol  
JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia;  Liu, Ming
收藏  |  浏览/下载：25/0  |  提交时间：2024/04/07
Acquired resistance  Cancer  NSCLC  JC-010a  SHP2  
Feasibility of increasing marine carbon storage through olivine addition 期刊论文
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, 2023, 卷号: 11, 期号: 6, 页码: 13
作者:  Wang, Bin;  Gao, Xuelu;  Song, Jinming;  Li, Xuegang;  Yuan, Huamao;  Xie, Lei;  Zhao, Jianmin;  Xing, Qianguo;  Qin, Song
Adobe PDF(1879Kb)  |  收藏  |  浏览/下载：41/0  |  提交时间：2024/04/07
CO2 sequestration  Ocean alkalinity enhancement  Carbonate pump  Ocean geoengineering  Marine ecosystems  Ecological risk  
Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 266, 页码: 11
作者:  Ding, Kui;  Xu, Qinzeng;  Zhang, Xuelei;  Liu, Shilin
Adobe PDF(3947Kb)  |  收藏  |  浏览/下载：6/0  |  提交时间：2024/04/07
Apostichopus japonicus  BDE-47  Nervous system  UPLC-Triple-TOF-MS  Metabolite  Neurotoxicity  
Autophagy contributes to increase the content of intracellular free amino acids in hard clam (Mercenaria mercenaria) during prolonged exposure to hypersaline environments 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Zou, Yan;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Song, Hao;  Zhang, Tao
Adobe PDF(5375Kb)  |  收藏  |  浏览/下载：205/1  |  提交时间：2023/11/30
Hyposalinity  Hypersalinity  Transcriptome  Autophagy  Free amino acids  
ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 141, 页码: 11
作者:  Zhou, Cong;  Zou, Yan;  Hu, Zhi;  Yang, Mei-jie;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(8330Kb)  |  收藏  |  浏览/下载：36/1  |  提交时间：2024/04/07
Air exposure  Resistance  Haemocytes  Oxidative stress  Autophagy  
Metabolomic and transcriptomic analyses reveal response mechanisms of juvenile flounder (Paralichthys olivaceus) to sublethal methylmercury 期刊论文
FRONTIERS IN MARINE SCIENCE, 2022, 卷号: 9, 页码: 15
作者:  Ren, Zhonghua;  Ning, Junhao;  Cao, Liang;  Liu, Jinhu;  Zhan, Junfei;  Wang, Zhikang;  Yu, Junbao;  Yang, Jisong;  Lv, Zhenbo
Adobe PDF(4236Kb)  |  收藏  |  浏览/下载：159/0  |  提交时间：2023/01/04
methylmercury  paralichthys olivaceus  growth  metabolomic  transcriptomic  response mechanism  
Mechanisms of heat and hypoxia defense in hard clam: Insights from transcriptome analysis 期刊论文
AQUACULTURE, 2022, 卷号: 549, 页码: 11
作者:  Hu, Zhi;  Feng, Jie;  Song, Hao;  Zhou, Cong;  Yu, Zheng-Lin;  Yang, Mei-Jie;  Shi, Pu;  Guo, Yong-Jun;  Li, Yong-Ren;  Zhang, Tao
Adobe PDF(1663Kb)  |  收藏  |  浏览/下载：253/0  |  提交时间：2022/07/15
Mercenaria mercenaria  RNA-seq  Heat  Hypoxia  Global change  
Quantitative proteomics provides insight into the response of the marine dinoflagellate Prorocentrum donghaiense to changes in ambient phosphorus 期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2021, 页码: 14
作者:  Zhang, Shufeng;  Yuan, Chunjuan;  Chen, Ying;  Lin, Lin;  Wang, Dazhi
Adobe PDF(1187Kb)  |  收藏  |  浏览/下载：199/0  |  提交时间：2022/02/18
marine dinoflagellates  harmful algal blooms  Prorocentrum donghaiense  phosphorus  quantitative proteomics  
Emerging roles of circRNAs in regulating thermal and hypoxic stresses in Apostichopus japonicus (Echinodermata: Holothuroidea) 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 卷号: 228, 页码: 9
作者:  Huo, Da;  Sun, Lina;  Sun, Jingchun;  Lin, Chenggang;  Liu, Shilin;  Zhang, Libin;  Yang, Hongsheng
Adobe PDF(7579Kb)  |  收藏  |  浏览/下载：229/0  |  提交时间：2022/04/12
Circular RNA  Echinoderm  Heat  Anoxia  Environmental stress