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Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo 期刊论文
CHEMISTRY & BIODIVERSITY, 2024, 页码: 11
作者:  Sun, Hao;  Bai, Xiaoyi;  Zhang, Yiting;  Gao, Yanan;  Dai, Jiajia;  Xing, Pan;  Zhu, Jiqiang;  Liu, Ruihua;  Wang, Zemin;  Li, Xiangqian
收藏  |  浏览/下载:4/0  |  提交时间:2024/06/04
Anti-tumor  SHP2  Orthosteric inhibitor  Apoptosis  Bromophenol  
JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia;  Liu, Ming
收藏  |  浏览/下载:25/0  |  提交时间:2024/04/07
Acquired resistance  Cancer  NSCLC  JC-010a  SHP2  
Feasibility of increasing marine carbon storage through olivine addition 期刊论文
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, 2023, 卷号: 11, 期号: 6, 页码: 13
作者:  Wang, Bin;  Gao, Xuelu;  Song, Jinming;  Li, Xuegang;  Yuan, Huamao;  Xie, Lei;  Zhao, Jianmin;  Xing, Qianguo;  Qin, Song
Adobe PDF(1879Kb)  |  收藏  |  浏览/下载:45/0  |  提交时间:2024/04/07
CO2 sequestration  Ocean alkalinity enhancement  Carbonate pump  Ocean geoengineering  Marine ecosystems  Ecological risk  
Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 266, 页码: 11
作者:  Ding, Kui;  Xu, Qinzeng;  Zhang, Xuelei;  Liu, Shilin
Adobe PDF(3947Kb)  |  收藏  |  浏览/下载:6/0  |  提交时间:2024/04/07
Apostichopus japonicus  BDE-47  Nervous system  UPLC-Triple-TOF-MS  Metabolite  Neurotoxicity  
Autophagy contributes to increase the content of intracellular free amino acids in hard clam (Mercenaria mercenaria) during prolonged exposure to hypersaline environments 期刊论文
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 192, 页码: 11
作者:  Zhou, Cong;  Yang, Mei-jie;  Hu, Zhi;  Zou, Yan;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Song, Hao;  Zhang, Tao
Adobe PDF(5375Kb)  |  收藏  |  浏览/下载:207/1  |  提交时间:2023/11/30
Hyposalinity  Hypersalinity  Transcriptome  Autophagy  Free amino acids  
ROS-induced moderate autophagy of haemocytes confers resistance of Mercenaria mercenaria to air exposure stress 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2023, 卷号: 141, 页码: 11
作者:  Zhou, Cong;  Zou, Yan;  Hu, Zhi;  Yang, Mei-jie;  Shi, Pu;  Li, Yong-ren;  Guo, Yong-jun;  Zhang, Tao;  Song, Hao
Adobe PDF(8330Kb)  |  收藏  |  浏览/下载:38/1  |  提交时间:2024/04/07
Air exposure  Resistance  Haemocytes  Oxidative stress  Autophagy  
Metabolomic and transcriptomic analyses reveal response mechanisms of juvenile flounder (Paralichthys olivaceus) to sublethal methylmercury 期刊论文
FRONTIERS IN MARINE SCIENCE, 2022, 卷号: 9, 页码: 15
作者:  Ren, Zhonghua;  Ning, Junhao;  Cao, Liang;  Liu, Jinhu;  Zhan, Junfei;  Wang, Zhikang;  Yu, Junbao;  Yang, Jisong;  Lv, Zhenbo
Adobe PDF(4236Kb)  |  收藏  |  浏览/下载:159/0  |  提交时间:2023/01/04
methylmercury  paralichthys olivaceus  growth  metabolomic  transcriptomic  response mechanism  
Integrative omics analysis highlights the immunomodulatory effects of the parasitic dinoflagellate hhematodinium on crustacean hemocytes 期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2022, 卷号: 125, 页码: 35-47
作者:  Li, Meng;  Huang, Qian;  Lv, Xiaoyang;  Small, Hamish J.;  Li, Caiwen
Adobe PDF(7291Kb)  |  收藏  |  浏览/下载:226/0  |  提交时间:2022/07/18
Parasitic dinoflagellates  Hematodinium  Crustacean  Innate immunity  Host-parasite interaction  Omics study  
Mechanisms of heat and hypoxia defense in hard clam: Insights from transcriptome analysis 期刊论文
AQUACULTURE, 2022, 卷号: 549, 页码: 11
作者:  Hu, Zhi;  Feng, Jie;  Song, Hao;  Zhou, Cong;  Yu, Zheng-Lin;  Yang, Mei-Jie;  Shi, Pu;  Guo, Yong-Jun;  Li, Yong-Ren;  Zhang, Tao
Adobe PDF(1663Kb)  |  收藏  |  浏览/下载:254/0  |  提交时间:2022/07/15
Mercenaria mercenaria  RNA-seq  Heat  Hypoxia  Global change  
A self-powered rotating paper-based analytical device for sensing of thrombin 期刊论文
SENSORS AND ACTUATORS B-CHEMICAL, 2022, 卷号: 351, 页码: 8
作者:  Li, Qingling;  Xu, Yuehan;  Qi, Ji;  Zheng, Xiaoli;  Liu, Shudi;  Lin, Dong;  Zhang, Liangwei;  Liu, Ping;  Li, Bowei;  Chen, Lingxin
Adobe PDF(4216Kb)  |  收藏  |  浏览/下载:184/0  |  提交时间:2022/07/18
Microfluidic paper-based analytical devices  MuPAD  Biofuel cell  Electrochemical  Self-powered