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Development of an inducible Cas9 nickase and PAM-free Cas12a platform for bacterial diagnostics 期刊论文
TALANTA, 2023, 卷号: 265, 页码: 6
作者:  Hu, Yuanzhao;  Qiao, Yuefeng;  Li, Xiu-Qing;  Xiang, Zhenbo;  Wan, Yi;  Wang, Peng;  Yang, Zhiqing
Adobe PDF(3500Kb)  |  收藏  |  浏览/下载：79/0  |  提交时间：2023/12/13
Bacteria diagnostics  CRISPR-Cas9n  CRISPR-Cas12a  Strand displacement  
Rapid transition from continental breakup to igneous oceanic crust in the South China Sea 期刊论文
NATURE GEOSCIENCE, 2018, 卷号: 11, 期号: 10, 页码: 782-+
作者:  Larsen, H. C.;  Mohn, G.;  Nirrengarten, M.;  Sun, Z.;  Stock, J.;  Jian, Z.;  Klaus, A.;  Alvarez-Zarikian, C. A.;  Boaga, J.;  Bowden, S. A.;  Briais, A.;  Chen, Y.;  Cukur, D.;  Dadd, K.;  Ding, W.;  Dorais, M.;  Ferre, E. C.;  Ferreira, F.;  Furusawa, A.;  Gewecke, A.;  Hinojosa, J.;  Hofig, T. W.;  Hsiung, K. H.;  Huang, B.;  Huang, E.;  Huang, X. L.;  Jiang, S.;  Jin, H.;  Johnson, B. G.;  Kurzawski, R. M.;  Lei, C.;  Li, B.;  Li, L.;  Li, Y.;  Lin, J.;  Liu, C.;  Liu, Z.;  Luna, A. J.;  Lupi, C.;  McCarthy, A.;  Ningthoujam, L.;  Osono, N.;  Peate, D. W.;  Persaud, P.;  Qiu, N.;  Robinson, C.;  Satolli, S.;  Sauermilch, I;  Schindlbeck, J. C.;  Skinner, S.;  Straub, S.;  Su, X.;  Su, C.;  Tian, L.;  Van Der Zwan, F. M.;  Wan, S.;  Wu, H.;  Xiang, R.;  Yadav, R.;  Yi, L.;  Yu, P. S.;  Zhang, C.;  Zhang, J.;  Zhang, Y.;  Zhao, N.;  Zhong, G.;  Zhong, L.
Adobe PDF(2081Kb)  |  收藏  |  浏览/下载：336/0  |  提交时间：2019/08/27
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Guo, Shu-Ju;  Li, Xiang-Qian;  Chen, Xue-Chun;  Luo, Jiao;  Li, Chao;  Wang, Yi;  Shi, Da-Yong
Adobe PDF(824Kb)  |  收藏  |  浏览/下载：279/0  |  提交时间：2019/08/21
Pyrimidinedionederivatives  DPP-4 inhibitor  Molecular hybrid  SARs  Type 2 diabetes  
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 145-157
作者:  Li, Ning;  Wang, Li-Jun;  Jiang, Bo;  Li, Xiang-qian;  Guo, Chuan-long;  Guo, Shu-ju;  Shi, Da-Yong
Adobe PDF(1523Kb)  |  收藏  |  浏览/下载：288/0  |  提交时间：2019/08/21
DPP-4  Inhibitors  Analogs  Physico-chemical properties  SARs  Type 2 diabetes  
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway 期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 2, 页码: 13
作者:  Guo, Chuan-Long;  Wang, Li-Jun;  Zhao, Yue;  Liu, Hua;  Li, Xiang-Qian;  Jiang, Bo;  Luo, Jiao;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
Adobe PDF(5208Kb)  |  收藏  |  浏览/下载：320/0  |  提交时间：2019/08/21
bromophenol  molecular mechanisms  apoptosis  cell cycle  PI3K  Akt  p38  ERK  ROS  human lung cancer  
Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation 期刊论文
MARINE DRUGS, 2017, 卷号: 15, 期号: 11, 页码: 18
作者:  Wang, Li-Jun;  Guo, Chuan-Long;  Li, Xiang-Qian;  Wang, Shuai-Yu;  Jiang, Bo;  Zhao, Yue;  Luo, Jiao;  Xu, Kuo;  Liu, Hua;  Guo, Shu-Ju;  Wu, Ning;  Shi, Da-Yong
收藏  |  浏览/下载：289/0  |  提交时间：2019/07/15
bromophenol hybrids  anticancer  structure-activity relationships  ROS  apoptotic pathway  
Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 136, 页码: 348-359
作者:  Li, Xiang-Qian;  Xu, Qi;  Luo, Jiao;  Wang, Li-Jun;  Jiang, Bo;  Zhang, Ren-Shuai;  Shi, Da-Yong
Adobe PDF(1863Kb)  |  收藏  |  浏览/下载：312/0  |  提交时间：2017/10/09
Type 2 Diabetes  Ptp1b Inhibition  Selectivity  Competitive  Cellular Activity  
Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 8, 页码: 683-692
作者:  Wang, Bao-Cheng;  Wang, Li-Jun;  Jiang, Bo;  Wang, Shuai-Yu;  Wu, Ning;  Li, Xiang-Qian;  Shi, Da-Yong
Adobe PDF(1080Kb)  |  收藏  |  浏览/下载：273/0  |  提交时间：2017/09/30
Application Of Fluorine  Anticancer  Antimicrobial  Anti-inflammatory  Antivirus Activity  Drug Design  Importance Of Fluorinated Compounds  
Corrosion Resistance Research of ZnO/polyelectrolyte Composite Film 期刊论文
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2016, 卷号: 11, 期号: 10, 页码: 8512-8519
作者:  Lin, Zhi-feng;  Wang, Yi;  Zhang, Dun;  Li, Xiang-bo
Adobe PDF(133Kb)  |  收藏  |  浏览/下载：251/0  |  提交时间：2017/03/21
Zno  Pdda  Composite Film  Carbon Steel  Corrosion  
Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 2, 页码: 806-823
作者:  Wang, Li-Jun;  Wang, Shuai-Yu;  Jiang, Bo;  Wu, Ning;  Li, Xiang-Qian;  Wang, Bao-Cheng;  Luo, Jiao;  Yang, Meng;  Jin, Shui-Hua;  Shi, Da-Yong
Adobe PDF(1301Kb)  |  收藏  |  浏览/下载：244/0  |  提交时间：2015/06/15