| Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron | |
Wang, Jing1,3 ; Liu, Huaide2; Jin, Weihua1; Zhang, Hong1; Zhang, Quanbin1,3
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| 2016 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 卷号 | 82期号:2016页码:878-883 |
| 文章类型 | Article |
| 摘要 | Parkinson's disease (PD) is associated with progressive loss of dopaminergic neurons and more-widespread neuronal changes that cause complex symptoms. The aim of this study was to investigate the structure-activity relationship of sulfated hetero-polysaccharides (DF1) and sulfated galactofucan polysaccharides (DF2) on dopaminergic neuron in vivo and in vitro. Treatment with samples significantly ameliorated the depletion of both DA and TH-, Bcl-2- and Bax-positive neurons in MPTP-induced PD mice, DF1 showed the highest activity. The in vitro results found that DF1 and DF2 could reverse the decreased mitochondrial activity and the increased LDL release induced by MPP+ (P < 0.01 or P < 0.001) which provides further evidence that DF1 and DF2 also exerts a direct protection against the neuronal injury caused by MPP+. Furthermore, the administration of samples effectively decreased lipid peroxidation and increased the level/activities of GSH, GSH-PX, MDA and CAT in MPTP mice. Thus, the neuron protective effect may be mediated, in part, through antioxidant activity and the prevention of cell apoptosis. The chemical composition of DF1, DF2 and DF differed markedly, the DF1 fraction had the most complex chemical composition and showed the highest neuron protective activity. These results suggest that diverse monosaccharides and uronic acid might contribute to neuron protective activity. (C) 2015 Elsevier B.V. All rights reserved. |
| 关键词 | Sulfated Hetero-polysaccharides Sulfated Galactofucan Polysaccharides Neuron Protection |
| DOI | 10.1016/j.ijbiomac.2015.10.042 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367425100111 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/86653 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Nantong Univ, Sch Life Sci, Nantong 226019, Peoples R China 3.Chinese Acad Sci, Nantong Branch, Inst Oceanol, Nantong 226006, Jiangsu, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Liu, Huaide,Jin, Weihua,et al. Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,82(2016):878-883. |
| APA | Wang, Jing,Liu, Huaide,Jin, Weihua,Zhang, Hong,&Zhang, Quanbin.(2016).Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,82(2016),878-883. |
| MLA | Wang, Jing,et al."Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 82.2016(2016):878-883. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Structure-activity r（907KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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