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Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron
Wang, Jing1,3; Liu, Huaide2; Jin, Weihua1; Zhang, Hong1; Zhang, Quanbin1,3
AbstractParkinson's disease (PD) is associated with progressive loss of dopaminergic neurons and more-widespread neuronal changes that cause complex symptoms. The aim of this study was to investigate the structure-activity relationship of sulfated hetero-polysaccharides (DF1) and sulfated galactofucan polysaccharides (DF2) on dopaminergic neuron in vivo and in vitro. Treatment with samples significantly ameliorated the depletion of both DA and TH-, Bcl-2- and Bax-positive neurons in MPTP-induced PD mice, DF1 showed the highest activity. The in vitro results found that DF1 and DF2 could reverse the decreased mitochondrial activity and the increased LDL release induced by MPP+ (P < 0.01 or P < 0.001) which provides further evidence that DF1 and DF2 also exerts a direct protection against the neuronal injury caused by MPP+. Furthermore, the administration of samples effectively decreased lipid peroxidation and increased the level/activities of GSH, GSH-PX, MDA and CAT in MPTP mice. Thus, the neuron protective effect may be mediated, in part, through antioxidant activity and the prevention of cell apoptosis. The chemical composition of DF1, DF2 and DF differed markedly, the DF1 fraction had the most complex chemical composition and showed the highest neuron protective activity. These results suggest that diverse monosaccharides and uronic acid might contribute to neuron protective activity. (C) 2015 Elsevier B.V. All rights reserved.
KeywordSulfated Hetero-polysaccharides Sulfated Galactofucan Polysaccharides Neuron Protection
Indexed BySCI
WOS IDWOS:000367425100111
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Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Nantong Univ, Sch Life Sci, Nantong 226019, Peoples R China
3.Chinese Acad Sci, Nantong Branch, Inst Oceanol, Nantong 226006, Jiangsu, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
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GB/T 7714
Wang, Jing,Liu, Huaide,Jin, Weihua,et al. Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,82(2016):878-883.
APA Wang, Jing,Liu, Huaide,Jin, Weihua,Zhang, Hong,&Zhang, Quanbin.(2016).Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,82(2016),878-883.
MLA Wang, Jing,et al."Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 82.2016(2016):878-883.
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