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Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron
Wang, Jing1,3; Liu, Huaide2; Jin, Weihua1; Zhang, Hong1; Zhang, Quanbin1,3
2016
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号82期号:2016页码:878-883
文章类型Article
摘要Parkinson's disease (PD) is associated with progressive loss of dopaminergic neurons and more-widespread neuronal changes that cause complex symptoms. The aim of this study was to investigate the structure-activity relationship of sulfated hetero-polysaccharides (DF1) and sulfated galactofucan polysaccharides (DF2) on dopaminergic neuron in vivo and in vitro. Treatment with samples significantly ameliorated the depletion of both DA and TH-, Bcl-2- and Bax-positive neurons in MPTP-induced PD mice, DF1 showed the highest activity. The in vitro results found that DF1 and DF2 could reverse the decreased mitochondrial activity and the increased LDL release induced by MPP+ (P < 0.01 or P < 0.001) which provides further evidence that DF1 and DF2 also exerts a direct protection against the neuronal injury caused by MPP+. Furthermore, the administration of samples effectively decreased lipid peroxidation and increased the level/activities of GSH, GSH-PX, MDA and CAT in MPTP mice. Thus, the neuron protective effect may be mediated, in part, through antioxidant activity and the prevention of cell apoptosis. The chemical composition of DF1, DF2 and DF differed markedly, the DF1 fraction had the most complex chemical composition and showed the highest neuron protective activity. These results suggest that diverse monosaccharides and uronic acid might contribute to neuron protective activity. (C) 2015 Elsevier B.V. All rights reserved.
关键词Sulfated Hetero-polysaccharides Sulfated Galactofucan Polysaccharides Neuron Protection
DOI10.1016/j.ijbiomac.2015.10.042
收录类别SCI
语种英语
WOS记录号WOS:000367425100111
引用统计
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/86653
专题海洋生物技术研发中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Nantong Univ, Sch Life Sci, Nantong 226019, Peoples R China
3.Chinese Acad Sci, Nantong Branch, Inst Oceanol, Nantong 226006, Jiangsu, Peoples R China
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GB/T 7714
Wang, Jing,Liu, Huaide,Jin, Weihua,et al. Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,82(2016):878-883.
APA Wang, Jing,Liu, Huaide,Jin, Weihua,Zhang, Hong,&Zhang, Quanbin.(2016).Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,82(2016),878-883.
MLA Wang, Jing,et al."Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 82.2016(2016):878-883.
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