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The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction
Zhang, Jiajia1,2,3; Dai, Jiajia4; Zheng, Qingxuan4; Guo, Shuju1,2,3; Yu, Yanyan4; Hu, Wenpeng4; Gao, Yanan4; Shi, Dayong1,2,3,4
2020-02-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume21Issue:3Pages:15
Corresponding AuthorShi, Dayong(shidayong@sdu.edu.cn)
AbstractTriple negative breast cancer (TNBC) is the most aggressive cancer in women, and despite improved treatments, it remains a major cause of morbidity and mortality. We and others have demonstrated that different hybrid compounds targeting PARP/MAPK or other pathways to inhibit cancer progression may lead to promising therapeutic results. We introduced fluorine to alter the physical properties of the compounds. TSC-3C was one of the generated compounds. Upon treatment with TSC-3C, MDA-MB-231 cell proliferation, invasion, and migration were inhibited. TSC-3C induced MDA-MB-231 cell mitochondrial dysfunction and apoptosis, which may be caused by reducing the level of phosphorylated p44/42 MAPK (ERK1/2) and increasing the level of p-JNK. The present study may help to elucidate the role of the MAPK pathway in the development of breast cancer and may promote further research on halogenated heterocyclic compounds for the treatment of breast cancer.
Keywordtriple negative breast cancer MDA-MB-231 cells fluoro-thiazolylhydrazone MAPK pathway phosphorylated p44/42 MAPK (ERK1/2) phosphorylated c-Jun N-terminal kinase (p-JNK) apoptosis
DOI10.3390/ijms21031038
Indexed BySCI
Language英语
Funding ProjectNSFC-Shandong Joint Fund[U1706213] ; Sub-Class of Project of the National Natural Science Foundation of China[81803375] ; Surface Project of the National Natural Science Foundation of China[81773586] ; Surface Project of the National Natural Science Foundation of China[81872906] ; Sub-Class Project of the National Natural Science Foundation of China[81903354]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000522551606024
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/167269
Collection实验海洋生物学重点实验室
Corresponding AuthorShi, Dayong
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 10049, Peoples R China
4.Shandong Univ, Inst Microbial Technol, State Key Lab Microbial Technol, Jinan 250014, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhang, Jiajia,Dai, Jiajia,Zheng, Qingxuan,et al. The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(3):15.
APA Zhang, Jiajia.,Dai, Jiajia.,Zheng, Qingxuan.,Guo, Shuju.,Yu, Yanyan.,...&Shi, Dayong.(2020).The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(3),15.
MLA Zhang, Jiajia,et al."The Fluoro-Thiazolylhydrazone Compound TSC-3C Inhibits Triple Negative Breast Cancer (TNBC) Cell Line Activity by Promoting Apoptosis, Regulating the MAPK Pathway and Inducing Mitochondrial Dysfunction".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.3(2020):15.
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