Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway | |
| Liu, Yingjuan1,2,3; Geng, Lihua1,2,3; Zhang, Jingjing4; Wang, Jing1,2; Zhang, Qi1,2,3; Duan, Delin2,5; Zhang, Quanbin1,2 | |
| 2018-03-01 | |
| Source Publication | MARINE DRUGS
 |
| ISSN | 1660-3397 |
| Volume | 16Issue:3Pages:16 |
| Abstract | Parkinson's disease (PD) is a neurodegenerative movement disorder that is caused by a selective loss of dopaminergic neurons. Current PD treatments provide symptomatic relief but do not prevent or decelerate disease progression. Previous studies have suggested that acetylated and phosphorylated porphyran, derived from Porphyra, produces a neuroprotective effect against 6-OHDA-induced damage. Due to its antioxidant and neuroprotective potential, this study evaluates whether oligo-porphyran (OP) could be beneficial in an experimental model of PD in mice. The drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was intraperitoneally injected (20 mg/kg body weight) for seven days to simulate PD, followed by OP administration. We found that the behavioral deficits in spontaneous motor activity, latency to descend in a pole test, and suspension in a traction test were ameliorated, and excessive dopamine (DA) metabolism was suppressed after OP treatment. Additionally, we found that OP protected dopaminergic neurons by preventing MPTP-induced decreases in dopaminergic transporter and tyrosine hydroxylase protein levels. We speculated whether OP regulates a signaling pathway that affects the behavioral changes seen in PD mice. In this study, the PI3K/Akt/Bcl-2 pathway was detected. Our results demonstrate that OP increased the phosphorylation of PI3K/Akt/GSK-3 beta and inhibited the activation of caspase-3 and poly (ADP-ribose) polymerase, with changes in the Bax/Bcl-2 ratio. These results showed thatOPmight promote DA neuron survival in vivo by regulating the PI3K/Akt/Bcl-2 pathway, thereby ameliorating the neurobehavioral deficits in a PD mouse model and suggesting OP as a neuroprotective treatment for PD. |
| Keyword | oligo-porphyran PI3K/Akt apoptosis Parkinson's disease neurobehavior |
| DOI | 10.3390/md16030082 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Science and Technology Project of Shandong Province[2016GSF115031] ; Jiangsu Innovative & Entrepreneurial Talents Project ; Jiangsu Science & Technology Project[BE2015335] ; Science and Technology project of Fujian Province[2017T3015] ; Fujian STS Programme of Chinese Academy of Sciences ; Strategic Biological Resources Service Network Programme[ZSTH-025] ; Evaluation and Transformation of Active Natural Compounds ; Youth Innovation Promotion Association of CAS[2016190] ; Youth Innovation Promotion Association of CAS[2016190] ; Evaluation and Transformation of Active Natural Compounds ; Strategic Biological Resources Service Network Programme[ZSTH-025] ; Fujian STS Programme of Chinese Academy of Sciences ; Science and Technology project of Fujian Province[2017T3015] ; Jiangsu Science & Technology Project[BE2015335] ; Jiangsu Innovative & Entrepreneurial Talents Project ; Science and Technology Project of Shandong Province[2016GSF115031] |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:000428510200008 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/159199 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Zhang, Quanbin |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Eighth Peoples Hosp, Pharmaceut Dept, Qingdao 266000, Peoples R China 5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China |
| First Author Affilication | Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Liu, Yingjuan,Geng, Lihua,Zhang, Jingjing,et al. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway[J]. MARINE DRUGS,2018,16(3):16. |
| APA | Liu, Yingjuan.,Geng, Lihua.,Zhang, Jingjing.,Wang, Jing.,Zhang, Qi.,...&Zhang, Quanbin.(2018).Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway.MARINE DRUGS,16(3),16. |
| MLA | Liu, Yingjuan,et al."Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway".MARINE DRUGS 16.3(2018):16. |
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| File Name/Size | DocType | Version | Access | License | ||
| Oligo-Porphyran Amel（4919KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View | |
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