Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway

doi:10.3390/md16030082

IOCAS-IR > 实验海洋生物学重点实验室

	Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway
	Liu, Yingjuan 1,2,3; Geng, Lihua 1,2,3; Zhang, Jingjing 4; Wang, Jing 1,2; Zhang, Qi 1,2,3; Duan, Delin 2,5; Zhang, Quanbin 1,2
	2018-03-01
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	16 期号:3 页码:16
摘要	Parkinson's disease (PD) is a neurodegenerative movement disorder that is caused by a selective loss of dopaminergic neurons. Current PD treatments provide symptomatic relief but do not prevent or decelerate disease progression. Previous studies have suggested that acetylated and phosphorylated porphyran, derived from Porphyra, produces a neuroprotective effect against 6-OHDA-induced damage. Due to its antioxidant and neuroprotective potential, this study evaluates whether oligo-porphyran (OP) could be beneficial in an experimental model of PD in mice. The drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was intraperitoneally injected (20 mg/kg body weight) for seven days to simulate PD, followed by OP administration. We found that the behavioral deficits in spontaneous motor activity, latency to descend in a pole test, and suspension in a traction test were ameliorated, and excessive dopamine (DA) metabolism was suppressed after OP treatment. Additionally, we found that OP protected dopaminergic neurons by preventing MPTP-induced decreases in dopaminergic transporter and tyrosine hydroxylase protein levels. We speculated whether OP regulates a signaling pathway that affects the behavioral changes seen in PD mice. In this study, the PI3K/Akt/Bcl-2 pathway was detected. Our results demonstrate that OP increased the phosphorylation of PI3K/Akt/GSK-3 beta and inhibited the activation of caspase-3 and poly (ADP-ribose) polymerase, with changes in the Bax/Bcl-2 ratio. These results showed thatOPmight promote DA neuron survival in vivo by regulating the PI3K/Akt/Bcl-2 pathway, thereby ameliorating the neurobehavioral deficits in a PD mouse model and suggesting OP as a neuroprotective treatment for PD.
关键词	oligo-porphyran PI3K/Akt apoptosis Parkinson's disease neurobehavior
DOI	10.3390/md16030082
收录类别	SCI
语种	英语
资助项目	Science and Technology Project of Shandong Province[2016GSF115031] ; Jiangsu Innovative & Entrepreneurial Talents Project ; Jiangsu Science & Technology Project[BE2015335] ; Science and Technology project of Fujian Province[2017T3015] ; Fujian STS Programme of Chinese Academy of Sciences ; Strategic Biological Resources Service Network Programme[ZSTH-025] ; Evaluation and Transformation of Active Natural Compounds ; Youth Innovation Promotion Association of CAS[2016190] ; Youth Innovation Promotion Association of CAS[2016190] ; Evaluation and Transformation of Active Natural Compounds ; Strategic Biological Resources Service Network Programme[ZSTH-025] ; Fujian STS Programme of Chinese Academy of Sciences ; Science and Technology project of Fujian Province[2017T3015] ; Jiangsu Science & Technology Project[BE2015335] ; Jiangsu Innovative & Entrepreneurial Talents Project ; Science and Technology Project of Shandong Province[2016GSF115031]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000428510200008
出版者	MDPI
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/159199
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Quanbin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Eighth Peoples Hosp, Pharmaceut Dept, Qingdao 266000, Peoples R China 5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China
第一作者单位	实验海洋生物学重点实验室
通讯作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Liu, Yingjuan,Geng, Lihua,Zhang, Jingjing,et al. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway[J]. MARINE DRUGS,2018,16(3):16.
APA	Liu, Yingjuan.,Geng, Lihua.,Zhang, Jingjing.,Wang, Jing.,Zhang, Qi.,...&Zhang, Quanbin.(2018).Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway.MARINE DRUGS,16(3),16.
MLA	Liu, Yingjuan,et al."Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway".MARINE DRUGS 16.3(2018):16.

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