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Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway
Liu, Yingjuan1,2,3; Geng, Lihua1,2,3; Zhang, Jingjing4; Wang, Jing1,2; Zhang, Qi1,2,3; Duan, Delin2,5; Zhang, Quanbin1,2
2018-03-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume16Issue:3Pages:16
Corresponding AuthorZhang, Quanbin(qbzhang@qdio.ac.cn)
AbstractParkinson's disease (PD) is a neurodegenerative movement disorder that is caused by a selective loss of dopaminergic neurons. Current PD treatments provide symptomatic relief but do not prevent or decelerate disease progression. Previous studies have suggested that acetylated and phosphorylated porphyran, derived from Porphyra, produces a neuroprotective effect against 6-OHDA-induced damage. Due to its antioxidant and neuroprotective potential, this study evaluates whether oligo-porphyran (OP) could be beneficial in an experimental model of PD in mice. The drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was intraperitoneally injected (20 mg/kg body weight) for seven days to simulate PD, followed by OP administration. We found that the behavioral deficits in spontaneous motor activity, latency to descend in a pole test, and suspension in a traction test were ameliorated, and excessive dopamine (DA) metabolism was suppressed after OP treatment. Additionally, we found that OP protected dopaminergic neurons by preventing MPTP-induced decreases in dopaminergic transporter and tyrosine hydroxylase protein levels. We speculated whether OP regulates a signaling pathway that affects the behavioral changes seen in PD mice. In this study, the PI3K/Akt/Bcl-2 pathway was detected. Our results demonstrate that OP increased the phosphorylation of PI3K/Akt/GSK-3 beta and inhibited the activation of caspase-3 and poly (ADP-ribose) polymerase, with changes in the Bax/Bcl-2 ratio. These results showed thatOPmight promote DA neuron survival in vivo by regulating the PI3K/Akt/Bcl-2 pathway, thereby ameliorating the neurobehavioral deficits in a PD mouse model and suggesting OP as a neuroprotective treatment for PD.
Keywordoligo-porphyran PI3K/Akt apoptosis Parkinson's disease neurobehavior
DOI10.3390/md16030082
Indexed BySCI
Language英语
Funding ProjectEvaluation and Transformation of Active Natural Compounds ; Strategic Biological Resources Service Network Programme[ZSTH-025] ; Fujian STS Programme of Chinese Academy of Sciences ; Science and Technology project of Fujian Province[2017T3015] ; Jiangsu Science & Technology Project[BE2015335] ; Jiangsu Innovative & Entrepreneurial Talents Project ; Science and Technology Project of Shandong Province[2016GSF115031] ; Youth Innovation Promotion Association of CAS[2016190]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000428510200008
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/159199
Collection实验海洋生物学重点实验室
Corresponding AuthorZhang, Quanbin
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Qingdao Eighth Peoples Hosp, Pharmaceut Dept, Qingdao 266000, Peoples R China
5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Yingjuan,Geng, Lihua,Zhang, Jingjing,et al. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway[J]. MARINE DRUGS,2018,16(3):16.
APA Liu, Yingjuan.,Geng, Lihua.,Zhang, Jingjing.,Wang, Jing.,Zhang, Qi.,...&Zhang, Quanbin.(2018).Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway.MARINE DRUGS,16(3),16.
MLA Liu, Yingjuan,et al."Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway".MARINE DRUGS 16.3(2018):16.
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