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Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria
Sun, Yuan-yuan1,2,4; Liu, Li1,2,4; Li, Jun3; Sun, Li1,2
2016-02-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷号55期号:2016页码:194-202
文章类型Article
摘要Lectins are a group of sugar-binding proteins that are important factors of the innate immune system. In this study, we examined, in a comparative manner, the expression and function of three Bulb-type (B-type) mannose-specific lectins (named CsBML1, CsBML2, and CsBML3) from tongue sole. All three lectins possess three repeats of the conserved mannose binding motif QXDXNXVX'Y. Expression of CsBML1, CsBML2, and CsBML3 was most abundant in liver and upregulated by bacterial infection. Recombinant (r) CsBML1, CsBML2, and CsBML3 bound to a wide arrange of bacteria in a dose-dependent manner and with different affinities. All three lectins displayed mannose-specific and calcium-dependent agglutinating capacities but differed in agglutinating profiles. rCsBML1 and rCsBML2, but not rCsBML3, killed target bacteria in vitro and inhibited bacterial dissemination in fish tissues in vivo. These results indicate for the first time that in teleost, different members of B-type mannose-specific lectins likely play different roles in antibacterial immunity. (C) 2015 Elsevier Ltd. All rights reserved.
关键词B-type Lectin Cynoglossus Semilaevis Agglutination Antibacterial
DOI10.1016/j.dci.2015.10.003
收录类别SCI
语种英语
WOS记录号WOS:000368382200022
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/95218
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Lake Super State Univ, Sch Biol Sci, Sault Ste Marie, MI USA
4.Univ Chinese Acad Sci, Beijing, Peoples R China
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Sun, Yuan-yuan,Liu, Li,Li, Jun,et al. Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2016,55(2016):194-202.
APA Sun, Yuan-yuan,Liu, Li,Li, Jun,&Sun, Li.(2016).Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,55(2016),194-202.
MLA Sun, Yuan-yuan,et al."Three novel B-type mannose-specific lectins of Cynoglossus semilaevis possess varied antibacterial activities against Gram-negative and Gram-positive bacteria".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 55.2016(2016):194-202.
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