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A CCL21 chemokine of tongue sole (Cynoglossus semilaevis) promotes host resistance against bacterial infection
Wang, Ming-qing1,2; Chi, Heng1,2; Li, Mo-fei1,2
2015-11-01
发表期刊FISH & SHELLFISH IMMUNOLOGY
卷号47期号:1页码:461-469
文章类型Article
摘要Chemokines are a large family of chemotactic cytokines. Based on the arrangement of the first two cysteine residues, chemokines are divided into four groups, one of which is the CC chemoldne group. In this study, we characterized a CC chemokine, CsCCL21, from half-smooth tongue sole (cynoglossus semilaevis), and analyzed its activity. CsCCL21 contains two conserved N-terminal cysteine residues in a NCCL motif and is phylogenetically related to the CCL19/21/25 subgroup of CC chemokines. CsCCL21 was constitutively expressed in nine tissues and significantly upregulated by bacterial and viral infection. The recombinant CsCCL21 (rCsCCL21) induced migration of peripheral blood leukocytes. When the two conserved cysteine residues in the NCCL motif were mutated, the chemotactic activity of rCsCCL21 was abolished. rCsCCL21 enhanced the resistance of tongue sole against bacterial infection, but the mutant protein with NCCL mutation lacked this antibacterial effect. Taken together, these results suggest that CsCCL21 is a functional CC chemokine with the ability to recruit leukocytes and is involved in antibacterial immunity in a manner that requires the conserved NCCL motif. (c) 2015 Elsevier Ltd. All rights reserved.
关键词Cynoglossus Semilaevis Chemokine Chemotaxis Antibacterial
DOI10.1016/j.fsi.2015.09.036
收录类别SCI
语种英语
WOS记录号WOS:000365053300053
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/82324
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
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Wang, Ming-qing,Chi, Heng,Li, Mo-fei. A CCL21 chemokine of tongue sole (Cynoglossus semilaevis) promotes host resistance against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2015,47(1):461-469.
APA Wang, Ming-qing,Chi, Heng,&Li, Mo-fei.(2015).A CCL21 chemokine of tongue sole (Cynoglossus semilaevis) promotes host resistance against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,47(1),461-469.
MLA Wang, Ming-qing,et al."A CCL21 chemokine of tongue sole (Cynoglossus semilaevis) promotes host resistance against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 47.1(2015):461-469.
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