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A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid
Chen, Yan1,2; Li, Yiwei1; Ma, Yaohong1; Meng, Qingjun1; Yan, Yan1; Shi, Jianguo1
2015-08-01
Source PublicationANALYTICAL SCIENCES
Volume31Issue:8Pages:799-803
SubtypeArticle
AbstractA nanocomposite platform built with multi-walled carbon nanotubes (MWCNTs) and nicotinamide adenine dinucleotide (NAD(+)) via a noncovalent interaction between the large it systems in NAD(+) molecules and MWCNTs on a glassy carbon substrate was successfully developed for the sensitive and selective detection of uric acid (UA) in the presence of ascorbic acid (AA), dopamine (DA). NAD(+) has an adenine subunit and a nicotinamide subunit, which enabled interaction with the purine subunit of UA through a strong pi-pi interaction to enhance the specificity of UA. Compared with a bare glassy carbon electrode (GCE) and MWCNTs/GCE, the MWCNTs-NAD(+)/GCE showed a low background current and a remarkable enhancement of the oxidation peak current of UA. Using differential pulse voltammetry (DPV), a high sensitivity for the determination of UA was explored for the MWCNTs-NAD(+) modified electrode. A linear relationship between the DPV peak current of UA and its concentration could be obtained in the range of 0.05 - 10 mu M with the detection limit as low as 10 nM (S/N = 3). This present strategy provides a novel and promising platform for the detection of UA in human urine and serum samples.
KeywordNanocomposite Modified Electrode Nicotinamide Adenine Dinucleotide Conjugative Effect Uric Acid
Indexed BySCI
Language英语
WOS IDWOS:000360256300010
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/50266
Collection实验海洋生物学重点实验室
Affiliation1.Shandong Acad Sci, Inst Biol, Lab Biosensors Shandong Prov, Jinan 250014, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Chen, Yan,Li, Yiwei,Ma, Yaohong,et al. A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid[J]. ANALYTICAL SCIENCES,2015,31(8):799-803.
APA Chen, Yan,Li, Yiwei,Ma, Yaohong,Meng, Qingjun,Yan, Yan,&Shi, Jianguo.(2015).A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid.ANALYTICAL SCIENCES,31(8),799-803.
MLA Chen, Yan,et al."A Nicotinamide Adenine Dinucleotide Dispersed Multi-walled Carbon Nanotubes Electrode for Direct and Selective Electrochemical Detection of Uric Acid".ANALYTICAL SCIENCES 31.8(2015):799-803.
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