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| Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media | |
Liu, Yang1,2 ; Li, Xiao-Ming1; Meng, Ling-Hong1,2; Jiang, Wen-Li3; Xu, Gang-Ming1; Huang, Cai-Guo3; Wang, Bin-Gui1
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| 2015-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| 卷号 | 78期号:6页码:1294-1299 |
| 文章类型 | Article |
| 摘要 | Chemical investigation of the marine-sponge-derived fungus Penicillium adametzioides AS-53 resulted in the identification of two new bisthiodiketopiperazine derivatives, adametizines A (1) and B (2), from cultivation in a liquid potato-dextrose broth (PDB) culture medium, whereas two new acorane sesquiterpenes, adametacorenols A (3) and B (4), were isolated from a rice solid culture medium. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The absolute configuration of compound 1 was determined by X-ray crystallographic analysis, and that of 3 was determined by modified Mosher's method. Compound 1 exhibited lethality against brine shrimp (Artemia salina) with an LD50 value of 4.8 mu M and inhibitory activities against Staphyloccocus aureus, Aeromonas hydrophilia, Vibrio spp. V. harveyi and V. parahaemolyticus, and Gaeumannomyces graminis with minimum inhibitory concentration values of 8, 8, 32, 8, and 16 mu g/mL, respectively. Chlorination at C-7 significantly increased the brine shrimp lethality and antimicrobial activity of the bisthiodiketopiperazines. |
| DOI | 10.1021/acs.jnatprod.5b00102 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000357138300014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/49046 |
| 专题 | 实验海洋生物学重点实验室 海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Li, Xiao-Ming,Meng, Ling-Hong,et al. Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(6):1294-1299. |
| APA | Liu, Yang.,Li, Xiao-Ming.,Meng, Ling-Hong.,Jiang, Wen-Li.,Xu, Gang-Ming.,...&Wang, Bin-Gui.(2015).Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media.JOURNAL OF NATURAL PRODUCTS,78(6),1294-1299. |
| MLA | Liu, Yang,et al."Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media".JOURNAL OF NATURAL PRODUCTS 78.6(2015):1294-1299. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Bisthiodiketopiperaz（819KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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