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Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media
Liu, Yang1,2; Li, Xiao-Ming1; Meng, Ling-Hong1,2; Jiang, Wen-Li3; Xu, Gang-Ming1; Huang, Cai-Guo3; Wang, Bin-Gui1
2015-06-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume78Issue:6Pages:1294-1299
SubtypeArticle
AbstractChemical investigation of the marine-sponge-derived fungus Penicillium adametzioides AS-53 resulted in the identification of two new bisthiodiketopiperazine derivatives, adametizines A (1) and B (2), from cultivation in a liquid potato-dextrose broth (PDB) culture medium, whereas two new acorane sesquiterpenes, adametacorenols A (3) and B (4), were isolated from a rice solid culture medium. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The absolute configuration of compound 1 was determined by X-ray crystallographic analysis, and that of 3 was determined by modified Mosher's method. Compound 1 exhibited lethality against brine shrimp (Artemia salina) with an LD50 value of 4.8 mu M and inhibitory activities against Staphyloccocus aureus, Aeromonas hydrophilia, Vibrio spp. V. harveyi and V. parahaemolyticus, and Gaeumannomyces graminis with minimum inhibitory concentration values of 8, 8, 32, 8, and 16 mu g/mL, respectively. Chlorination at C-7 significantly increased the brine shrimp lethality and antimicrobial activity of the bisthiodiketopiperazines.
DOI10.1021/acs.jnatprod.5b00102
Indexed BySCI
Language英语
WOS IDWOS:000357138300014
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/49046
Collection实验海洋生物学重点实验室
海洋生态与环境科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Liu, Yang,Li, Xiao-Ming,Meng, Ling-Hong,et al. Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(6):1294-1299.
APA Liu, Yang.,Li, Xiao-Ming.,Meng, Ling-Hong.,Jiang, Wen-Li.,Xu, Gang-Ming.,...&Wang, Bin-Gui.(2015).Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media.JOURNAL OF NATURAL PRODUCTS,78(6),1294-1299.
MLA Liu, Yang,et al."Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media".JOURNAL OF NATURAL PRODUCTS 78.6(2015):1294-1299.
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