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Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media
Liu, Yang1,2; Li, Xiao-Ming1; Meng, Ling-Hong1,2; Jiang, Wen-Li3; Xu, Gang-Ming1; Huang, Cai-Guo3; Wang, Bin-Gui1
2015-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号78期号:6页码:1294-1299
文章类型Article
摘要Chemical investigation of the marine-sponge-derived fungus Penicillium adametzioides AS-53 resulted in the identification of two new bisthiodiketopiperazine derivatives, adametizines A (1) and B (2), from cultivation in a liquid potato-dextrose broth (PDB) culture medium, whereas two new acorane sesquiterpenes, adametacorenols A (3) and B (4), were isolated from a rice solid culture medium. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The absolute configuration of compound 1 was determined by X-ray crystallographic analysis, and that of 3 was determined by modified Mosher's method. Compound 1 exhibited lethality against brine shrimp (Artemia salina) with an LD50 value of 4.8 mu M and inhibitory activities against Staphyloccocus aureus, Aeromonas hydrophilia, Vibrio spp. V. harveyi and V. parahaemolyticus, and Gaeumannomyces graminis with minimum inhibitory concentration values of 8, 8, 32, 8, and 16 mu g/mL, respectively. Chlorination at C-7 significantly increased the brine shrimp lethality and antimicrobial activity of the bisthiodiketopiperazines.
DOI10.1021/acs.jnatprod.5b00102
收录类别SCI
语种英语
WOS记录号WOS:000357138300014
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/49046
专题实验海洋生物学重点实验室
海洋生态与环境科学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
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Liu, Yang,Li, Xiao-Ming,Meng, Ling-Hong,et al. Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(6):1294-1299.
APA Liu, Yang.,Li, Xiao-Ming.,Meng, Ling-Hong.,Jiang, Wen-Li.,Xu, Gang-Ming.,...&Wang, Bin-Gui.(2015).Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media.JOURNAL OF NATURAL PRODUCTS,78(6),1294-1299.
MLA Liu, Yang,et al."Bisthiodiketopiperazines and Acorane Sesquiterpenes Produced by the Marine-Derived Fungus Penicillium adametzioides AS-53 on Different Culture Media".JOURNAL OF NATURAL PRODUCTS 78.6(2015):1294-1299.
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