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Effects of fucoidan on chronic renal failure in rats
Zhang, QB; Li, Z; Xu, ZH; Niu, XZ; Zhang, H
2003-06-01
Source PublicationPLANTA MEDICA
Volume69Issue:6Pages:537-541
SubtypeArticle
AbstractThe effects of fucoidan on chronic renal failure (CRF) were investigated in vivo in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinine and urea nitrogen levels. Histopathological changes of renal. tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent.
KeywordLaminaria Japonica Laminariaceae Fucoidan Chronic Renal Failure Serum Creatinine Serum Urea Nitrogen
Indexed BySCI
Language英语
WOS IDWOS:000184144600011
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Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/33004
Collection海洋生物技术研发中心
Affiliation1.Acad Sinica, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, QB,Li, Z,Xu, ZH,et al. Effects of fucoidan on chronic renal failure in rats[J]. PLANTA MEDICA,2003,69(6):537-541.
APA Zhang, QB,Li, Z,Xu, ZH,Niu, XZ,&Zhang, H.(2003).Effects of fucoidan on chronic renal failure in rats.PLANTA MEDICA,69(6),537-541.
MLA Zhang, QB,et al."Effects of fucoidan on chronic renal failure in rats".PLANTA MEDICA 69.6(2003):537-541.
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