IOCAS-IR  > 实验海洋生物学重点实验室
Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources
Lin, Xiukun1; Liu, Ming1; Hu, Chaoxin1; Liao, D. Joshua2
2010-06-01
Source PublicationCURRENT DRUG TARGETS
Volume11Issue:6Pages:708-715
SubtypeReview
AbstractApoptosis as a form of programmed cell death is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. In an in vivo situation, apoptosis functions to eliminate potentially deleterious cells without causing such adverse effects as inflammatory response and ensuing scar formation. Therefore, targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Marine natural products have become an important source in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. Although lack of an analog of a long ethno-medical history for finding clues, as compared with terrestrial habitats, still hinders the progress, an increasing number of compounds have been isolated from marine organisms that have been found to possess apoptosis-inducing and anticancer activities. This primer summarizes several such compounds, based on their effects on apoptotic signaling pathways, although most of these products have not yet been studied in depth for their mechanisms of action.
KeywordApoptosis Cancer Targets Marine Organisms Natural Products
Indexed BySCI
Language英语
WOS IDWOS:000277123000006
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/32923
Collection实验海洋生物学重点实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
Recommended Citation
GB/T 7714
Lin, Xiukun,Liu, Ming,Hu, Chaoxin,et al. Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources[J]. CURRENT DRUG TARGETS,2010,11(6):708-715.
APA Lin, Xiukun,Liu, Ming,Hu, Chaoxin,&Liao, D. Joshua.(2010).Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources.CURRENT DRUG TARGETS,11(6),708-715.
MLA Lin, Xiukun,et al."Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources".CURRENT DRUG TARGETS 11.6(2010):708-715.
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