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Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources
Lin, Xiukun1; Liu, Ming1; Hu, Chaoxin1; Liao, D. Joshua2
2010-06-01
发表期刊CURRENT DRUG TARGETS
卷号11期号:6页码:708-715
文章类型Review
摘要Apoptosis as a form of programmed cell death is a critical defense mechanism against the formation and progression of cancer and exhibits distinct morphological and biochemical traits. In an in vivo situation, apoptosis functions to eliminate potentially deleterious cells without causing such adverse effects as inflammatory response and ensuing scar formation. Therefore, targeting apoptotic pathways becomes an intriguing strategy for the development of chemotherapeutic agents. Marine natural products have become an important source in the discovery of antitumor drugs, especially when modern technology makes it more and more feasible to collect organisms from seas. Although lack of an analog of a long ethno-medical history for finding clues, as compared with terrestrial habitats, still hinders the progress, an increasing number of compounds have been isolated from marine organisms that have been found to possess apoptosis-inducing and anticancer activities. This primer summarizes several such compounds, based on their effects on apoptotic signaling pathways, although most of these products have not yet been studied in depth for their mechanisms of action.
关键词Apoptosis Cancer Targets Marine Organisms Natural Products
收录类别SCI
语种英语
WOS记录号WOS:000277123000006
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/32923
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
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GB/T 7714
Lin, Xiukun,Liu, Ming,Hu, Chaoxin,et al. Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources[J]. CURRENT DRUG TARGETS,2010,11(6):708-715.
APA Lin, Xiukun,Liu, Ming,Hu, Chaoxin,&Liao, D. Joshua.(2010).Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources.CURRENT DRUG TARGETS,11(6),708-715.
MLA Lin, Xiukun,et al."Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources".CURRENT DRUG TARGETS 11.6(2010):708-715.
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