Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135

doi:10.1021/np4011037

IOCAS-IR > 实验海洋生物学重点实验室

	Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135
	Du, Feng-Yu 1; Zhang, Peng1,2 ; Li, Xiao-Ming 1; Li, Chun-Shun 1; Cui, Chuan-Ming 1; Wang, Bin-Gui1 ; Li, XM (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China.
	2014-05-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
卷号	77 期号:5 页码:1164-1169
文章类型	Article
摘要	Three new cyclohexadepsipeptides of the isaridin class including isaridin G (1), desmethylisaridin G (2), and desmethylisaridin C1 (3), along with three related known metabolites (4-6), were isolated and identified from the marine bryozoan-derived fungus Beauveria felina EN-135. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, and the structures and absolute configurations of compounds 1-3 were confirmed by single-crystal X-ray diffraction analysis. The crystal structures showed the presence of beta-turns for the Tyr(3)/N-Me-Val(4) and Phe(3)/N-Me-Val(4) amide bonds in compounds 2 and 3, respectively, in the cis conformations, which were opposite other reported isaridins. The conformations of the HMPA(1)-Pro(2) amide bond in compound 2 are different in the solution and in the crystal structures, which showed trans and cis geometries, respectively, while compounds 1 and 3 do not exhibit this phenomenon. Each of the isolated compounds was evaluated for antimicrobial activity and brine shrimp lethality. Compound 3 exhibited antibacterial activity against E. coli with an MIC value of 8 mu g/mL.
学科领域	Plant Sciences ; Pharmacology & Pharmacy
DOI	10.1021/np4011037
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000336510700011
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/24099
专题	实验海洋生物学重点实验室
通讯作者	Li, XM (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Du, Feng-Yu,Zhang, Peng,Li, Xiao-Ming,et al. Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(5):1164-1169.
APA	Du, Feng-Yu.,Zhang, Peng.,Li, Xiao-Ming.,Li, Chun-Shun.,Cui, Chuan-Ming.,...&Li, XM .(2014).Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135.JOURNAL OF NATURAL PRODUCTS,77(5),1164-1169.
MLA	Du, Feng-Yu,et al."Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135".JOURNAL OF NATURAL PRODUCTS 77.5(2014):1164-1169.

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Cyclohexadepsipeptid（1816KB）			限制开放	ODC PDDL	浏览