Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo

doi:10.1002/mabi.202300292

IOCAS-IR > 实验海洋生物学重点实验室

	Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo
	Wu, Yumeng 1; Geng, Lihua 1,2; Zhang, Jingjing 1,3; Wu, Ning 1,2; Yang, Yue 1,2; Zhang, Quanbin 1,2; Duan, Delin 1,2; Wang, Jing1,2
	2023-12-03
发表期刊	MACROMOLECULAR BIOSCIENCE
ISSN	1616-5187
页码	16
通讯作者	Wang, Jing(jingwang@qdio.ac.cn)
摘要	Seaweed polysaccharides can be used for protective skin photoaging which is caused by long-term exposure to ultraviolet B (UVB). In this study, a multifunctional composite hydrogel (FACP5) is prepared using sulfated galactofucan polysaccharides, alginate oligosaccharides as active ingredients, and polyacrylonitrile modified kappa-Carrageenan as substrate. The properties of FACP5 show that it has good water retention, spreadability, and adhesion. The antiphotoaging activity is evaluated in vitro and in vivo. In vitro experiments demonstrate that the components of FACP5 exhibit good biocompatibility, antioxidant, and anti-tyrosinase activities, and could reduce the cell death rate induced by UVB. In vivo experiments demonstrate that, compared with the mice skin in model group, the skin water content treated with FACP5 increases by 29.80%; the thicknesses of epidermis and dermis decrease by 53.56% and 43.98%, respectively; the activities of catalase and superoxide dismutase increase by 1.59 and 0.72 times, respectively; the contents of interleukin-6 and tumor necrosis factor-alpha decrease by 19.21% and 17.85%, respectively; hydroxyproline content increases by 32.42%; the expression level of matrix metalloproteinase-3 downregulates by 42.80%. These results indicate that FACP5 has skin barrier repairing, antioxidant, anti-inflammatory, and inhibiting collagen degradation activies, FACP5 can be used as a skin protection remedy for photoaging. Composite hydrogel (FACP5) is prepared by seaweed polysaccharides. FACP5 components exhibit good biocompatibility, antioxidant, and anti-tyrosinase activities, and reduce the cell death rate induced by ultraviolet B. FACP5 is characterized by viscosity, spreadability, and porous structure. In photodamaged skin, it plays a role in repairing the barrier, reducing the level of oxidative stress and inflammation, and inhibiting collagen degradation.image
关键词	alginate oligosaccharides multifunctional composite hydrogel photoaging sulfated galactofucan polysaccharides ultraviolet B
DOI	10.1002/mabi.202300292
收录类别	SCI
语种	英语
资助项目	Asia Collaboration Project on Development of Ecological Marine Ranching ; Shandong Provincial Natural Science Foundation[ZR2022MD007] ; Science and Technology project of Fujian Province[2022T3024]
WOS研究方向	Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS记录号	WOS:001113469400001
出版者	WILEY-V C H VERLAG GMBH
WOS关键词	SARGASSUM-FUSIFORME ; SKIN ; MECHANISMS ; INHIBITOR ; RADIATION ; FUCOIDAN
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/184129
专题	实验海洋生物学重点实验室
通讯作者	Wang, Jing
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 168 Wenhai Rd, Qingdao 266237, Peoples R China 3.Qingdao Eighth Peoples Hosp, Dept Pharm, 84 Fengshan Rd, Qingdao 266121, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wu, Yumeng,Geng, Lihua,Zhang, Jingjing,et al. Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo[J]. MACROMOLECULAR BIOSCIENCE,2023:16.
APA	Wu, Yumeng.,Geng, Lihua.,Zhang, Jingjing.,Wu, Ning.,Yang, Yue.,...&Wang, Jing.(2023).Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo.MACROMOLECULAR BIOSCIENCE,16.
MLA	Wu, Yumeng,et al."Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo".MACROMOLECULAR BIOSCIENCE (2023):16.

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