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Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo
Wu, Yumeng1; Geng, Lihua1,2; Zhang, Jingjing1,3; Wu, Ning1,2; Yang, Yue1,2; Zhang, Quanbin1,2; Duan, Delin1,2; Wang, Jing1,2
2023-12-03
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Pages16
Corresponding AuthorWang, Jing(jingwang@qdio.ac.cn)
AbstractSeaweed polysaccharides can be used for protective skin photoaging which is caused by long-term exposure to ultraviolet B (UVB). In this study, a multifunctional composite hydrogel (FACP5) is prepared using sulfated galactofucan polysaccharides, alginate oligosaccharides as active ingredients, and polyacrylonitrile modified kappa-Carrageenan as substrate. The properties of FACP5 show that it has good water retention, spreadability, and adhesion. The antiphotoaging activity is evaluated in vitro and in vivo. In vitro experiments demonstrate that the components of FACP5 exhibit good biocompatibility, antioxidant, and anti-tyrosinase activities, and could reduce the cell death rate induced by UVB. In vivo experiments demonstrate that, compared with the mice skin in model group, the skin water content treated with FACP5 increases by 29.80%; the thicknesses of epidermis and dermis decrease by 53.56% and 43.98%, respectively; the activities of catalase and superoxide dismutase increase by 1.59 and 0.72 times, respectively; the contents of interleukin-6 and tumor necrosis factor-alpha decrease by 19.21% and 17.85%, respectively; hydroxyproline content increases by 32.42%; the expression level of matrix metalloproteinase-3 downregulates by 42.80%. These results indicate that FACP5 has skin barrier repairing, antioxidant, anti-inflammatory, and inhibiting collagen degradation activies, FACP5 can be used as a skin protection remedy for photoaging. Composite hydrogel (FACP5) is prepared by seaweed polysaccharides. FACP5 components exhibit good biocompatibility, antioxidant, and anti-tyrosinase activities, and reduce the cell death rate induced by ultraviolet B. FACP5 is characterized by viscosity, spreadability, and porous structure. In photodamaged skin, it plays a role in repairing the barrier, reducing the level of oxidative stress and inflammation, and inhibiting collagen degradation.image
Keywordalginate oligosaccharides multifunctional composite hydrogel photoaging sulfated galactofucan polysaccharides ultraviolet B
DOI10.1002/mabi.202300292
Indexed BySCI
Language英语
Funding ProjectAsia Collaboration Project on Development of Ecological Marine Ranching ; Shandong Provincial Natural Science Foundation[ZR2022MD007] ; Science and Technology project of Fujian Province[2022T3024]
WOS Research AreaBiochemistry & Molecular Biology ; Materials Science ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science
WOS IDWOS:001113469400001
PublisherWILEY-V C H VERLAG GMBH
WOS KeywordSARGASSUM-FUSIFORME ; SKIN ; MECHANISMS ; INHIBITOR ; RADIATION ; FUCOIDAN
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/184129
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Jing
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 168 Wenhai Rd, Qingdao 266237, Peoples R China
3.Qingdao Eighth Peoples Hosp, Dept Pharm, 84 Fengshan Rd, Qingdao 266121, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wu, Yumeng,Geng, Lihua,Zhang, Jingjing,et al. Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo[J]. MACROMOLECULAR BIOSCIENCE,2023:16.
APA Wu, Yumeng.,Geng, Lihua.,Zhang, Jingjing.,Wu, Ning.,Yang, Yue.,...&Wang, Jing.(2023).Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo.MACROMOLECULAR BIOSCIENCE,16.
MLA Wu, Yumeng,et al."Preparation of Multifunctional Seaweed Polysaccharides Derivatives Composite Hydrogel to Protect Ultraviolet B-Induced Photoaging In Vitro and In Vivo".MACROMOLECULAR BIOSCIENCE (2023):16.
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