Opportunities and challenges of fucoidan for tumors therapy

doi:10.1016/j.carbpol.2023.121555

IOCAS-IR > 实验海洋生物学重点实验室

	Opportunities and challenges of fucoidan for tumors therapy
	Yu, Haoyu 1,2,3,4; Zhang, Quanbin 1,2,4; Farooqi, Ammad Ahmad 5; Wang, Jing1,2,4 ; Yue, Yang1,2 ; Geng, Lihua 1,2; Wu, Ning 1,2,3,4,6
	2024-01-15
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	324 页码:13
通讯作者	Wu, Ning(wuning@qdio.ac.cn)
摘要	The large-scale collections, screening and discovery of biologically active and pharmacologically significant marine-derived natural products have garnered tremendous attraction. Edible brown algae are rich in fucoidan. Importantly, fucoidan has been reported to inhibit carcinogenesis and metastasis mainly through the regulation of deregulated cell signaling pathways. This review summarizes the structural features of fucoidan, including monosaccharide type, sulfate content, and main chain structure. We have set spotlight on fucoidan-mediated tumor suppressive effects in cell cultures studies and tumor-bearing rodent models. Fucoidan exerts antitumor effects primarily through the inhibition of tumor cell viability, proliferation and metastatic dissemination of cancer cells from primary tumor sites to distant secondary sites. Fucoidan not only promotes immunological responses in tumor microenvironment but also induces apoptotic death in cancer cells. In addition, fucoidan can be used as a dietary supplement for preventive purposes, in combination with other drugs as complementary and alternative medicine or with nanoparticle modifications will be the future of fucoidan use. Cutting-edge research related to fucoidan has catalyzed the transition of fucoidan from preclinical studies to different phases of clinical trials. Rationally designed clinical trials for the critical evaluation of fucoidan against different cancers will be valuable to reap full benefits.
关键词	Brown algae Fucoidan Structure Anti-tumor
DOI	10.1016/j.carbpol.2023.121555
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42176137]
WOS研究方向	Chemistry ; Polymer Science
WOS类目	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:001112283600001
出版者	ELSEVIER SCI LTD
WOS关键词	MOLECULAR-WEIGHT FUCOIDAN ; UNDARIA-PINNATIFIDA FUCOIDAN ; ACUTE PROMYELOCYTIC LEUKEMIA ; BLADDER-CANCER CELLS ; NATURAL-KILLER-CELLS ; GROWTH IN-VIVO ; BREAST-CANCER ; TURBINARIA-CONOIDES ; DOWN-REGULATION ; STRUCTURAL ELUCIDATION
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183996
专题	实验海洋生物学重点实验室
通讯作者	Wu, Ning
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Dept Drugs & Bioprod, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Inst Biomed & Genet Engn IBGE, Dept Mol Oncol, Islamabad 54000, Pakistan 6.7 Nanhai Rd, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yu, Haoyu,Zhang, Quanbin,Farooqi, Ammad Ahmad,et al. Opportunities and challenges of fucoidan for tumors therapy[J]. CARBOHYDRATE POLYMERS,2024,324:13.
APA	Yu, Haoyu.,Zhang, Quanbin.,Farooqi, Ammad Ahmad.,Wang, Jing.,Yue, Yang.,...&Wu, Ning.(2024).Opportunities and challenges of fucoidan for tumors therapy.CARBOHYDRATE POLYMERS,324,13.
MLA	Yu, Haoyu,et al."Opportunities and challenges of fucoidan for tumors therapy".CARBOHYDRATE POLYMERS 324(2024):13.