Comparative chromatin dynamics reveal differential thermal tolerance mechanisms between two congeneric oyster species

doi:10.1016/j.aquaculture.2023.740177

IOCAS-IR

	Comparative chromatin dynamics reveal differential thermal tolerance mechanisms between two congeneric oyster species
	Wang, Chaogang 1,2,3,4; Jiang, Zhuxiang 1,2,3,4; Du, Mingyang 1,2,3,4; Li, Qingyuan 1,2,3,4; Cong, Rihao 1,2,3,7,8; Wang, Wei 1,2,6,7,8; Zhang, Guofan 1,2,3,5,7,8; Li, Li 1,2,4,5,6,7
	2024-01-30
发表期刊	AQUACULTURE
ISSN	0044-8486
卷号	579 页码:16
通讯作者	Li, Li(lili@qdio.ac.cn)
摘要	Oysters, being globally farmed bivalve of significant economic and ecological value, are increasingly confronted with heat stress induced by global warming, such as the frequent occurrence of mass summer mortality events worldwide. The role of epigenetics in adapting to high-temperature environments has garnered growing attention; however, its application in oysters remains poorly understood. In this study, we conducted a comparative analysis between two closely related oyster species (the relatively thermosensitive Crassostrea gigas and the relatively thermotolerant Crassostrea angulata) using ATAC-Seq and RNA-Seq to reveal the differential thermal tolerance mechanisms at the chromatin dynamics level in response to high-temperature stress. The comparative analysis showed that the inhibitor of apoptosis protein (IAP) family and its associated apoptosis pathways were the major divergent pathway between the two species. The promoter regions of differentially expressed genes in C. gigas under heat stress were found to be enriched with motifs such as Foxp1, Foxk2, Myc, Cebpd, Foxo3, and Hsf1 motifs and expressed genes related to molecular chaperones, including heat shock protein family. And C. angulata activated the genes related to anti-apoptosis, DNA damage repair, and fatty acid synthesis (decreasing fatty acid unsaturation of membrane to regulate membrane fluidity). These findings suggest that C. angulata may have evolved a more centralized and energy-efficient transcriptional regulatory network at the genomic level, thereby facilitating its long-term adaptation to relatively high temperature environments. Furthermore, the key transcription factor Hsf1, involved in heat shock responses, may contribute to the differential heat response patterns in C. gigas and C. angulata through divergent expression levels of its alternatively spliced isoforms (Hsf1a and Hsf1d). Our work will contribute to predicting the adaptive potential of oysters and other marine invertebrates in facing future global warming, and provide a theoretical foundation for genetic improvement of resistance traits and sustainable development of oyster industry.
关键词	Crassostrea gigas Crassostrea angulata ATAC-seq RNA-Seq Thermal tolerance
DOI	10.1016/j.aquaculture.2023.740177
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2022YFD2400304] ; National Natural Science Foundation of China[32101353] ; Key Research and Development Program of Shandong[ZFJH202309] ; Key Research and Development Program of Shandong[2022LZGC015] ; Chinese Academy of Sciences[XDA23050402] ; Young Elite Scientists Sponsorship Program by China Association of Science and Technology[2021QNRC001] ; Key Technology Research and Industrialization Demonstration Projects of Qingdao[22-3-3-hygg-2-hy] ; Agriculture Research System of China of MOF and MARA[CARS-49]
WOS研究方向	Fisheries ; Marine & Freshwater Biology
WOS类目	Fisheries ; Marine & Freshwater Biology
WOS记录号	WOS:001094477900001
出版者	ELSEVIER
WOS关键词	BINDING PROTEIN DELTA ; HEAT-SHOCK ; CRASSOSTREA-GIGAS ; GENE-EXPRESSION ; TRANSCRIPTION FACTORS ; MOLECULAR CHAPERONES ; SUMMER MORTALITY ; ABSCISIC-ACID ; STRESS ; TEMPERATURE
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183836
通讯作者	Li, Li
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Laoshan Lab, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan, Peoples R China 6.Laoshan Lab, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China 7.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China 8.Shandong Technol Innovat Ctr Oyster Seed Ind, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Wang, Chaogang,Jiang, Zhuxiang,Du, Mingyang,et al. Comparative chromatin dynamics reveal differential thermal tolerance mechanisms between two congeneric oyster species[J]. AQUACULTURE,2024,579:16.
APA	Wang, Chaogang.,Jiang, Zhuxiang.,Du, Mingyang.,Li, Qingyuan.,Cong, Rihao.,...&Li, Li.(2024).Comparative chromatin dynamics reveal differential thermal tolerance mechanisms between two congeneric oyster species.AQUACULTURE,579,16.
MLA	Wang, Chaogang,et al."Comparative chromatin dynamics reveal differential thermal tolerance mechanisms between two congeneric oyster species".AQUACULTURE 579(2024):16.