Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression | |
Liu, Chengzhang1; Yuan, Jianbo1,2; Zhang, Xiaojun1,2; Jin, Songjun1,2; Li, Fuhua1,2,3; Xiang, Jianhai1,2,3
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| 2021-11-01 | |
| Source Publication | GENOMICS
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| ISSN | 0888-7543 |
| Volume | 113Issue:6Pages:3544-3555 |
| Corresponding Author | Zhang, Xiaojun(xjzhang@qdio.ac.cn) ; Xiang, Jianhai(jhxiang@qdio.ac.cn) |
| Abstract | Echinoderms are marine deuterostomes with fascinating adaptation features such as aestivation and organ regeneration. However, post-transcriptional gene regulation by microRNAs (miRNAs) underlying these features are largely unexplored. Here, using homology-based and de novo approaches supported by expression data, we provided a comprehensive annotation of miRNA genes in the sea cucumber Apostichopus japonicus. By linkage and phylogenic analyses, we characterized miRNA genomic organization, evolutionary history and expression regulation. The results showed that sea cucumbers evolved a large number of new miRNAs, which tended to form polycistronic clusters via tandem duplication that had been especially active in the echinoderms. Most new miRNAs were weakly expressed, but miRNA clustering increased the expression level of clustered new miRNAs. The most abundantly expressed new miRNAs were organized in a single tandem cluster (cluster n2), which was activated during aestivation and intestine regeneration. Overall, our analyses suggest that clustering of miRNAs is important for their evolutionary origin, expression control, and functional cooperation. |
| Keyword | microRNA miRNA cluster Sea cucumber Aestivation Regeneration |
| DOI | 10.1016/j.ygeno.2021.08.003 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Ocean Science Data Center, Institute of Oceanology, CAS ; National Natural Science Foundation of China[31772885] ; National Key R&D Program of China[2018YFD0900103] ; Senior User Project of RV KEXUE[KEXUE2018G19] |
| WOS Research Area | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS Subject | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS ID | WOS:000703997800002 |
| Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/176495 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Zhang, Xiaojun; Xiang, Jianhai |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Liu, Chengzhang,Yuan, Jianbo,Zhang, Xiaojun,et al. Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression[J]. GENOMICS,2021,113(6):3544-3555. |
| APA | Liu, Chengzhang,Yuan, Jianbo,Zhang, Xiaojun,Jin, Songjun,Li, Fuhua,&Xiang, Jianhai.(2021).Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression.GENOMICS,113(6),3544-3555. |
| MLA | Liu, Chengzhang,et al."Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression".GENOMICS 113.6(2021):3544-3555. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S088875432100（4047KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | View | |
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